Inducing Ectopic T Cell Clusters Using Stromal Vascular Fraction Spheroid-Based Immunotherapy to Enhance Anti-Tumor Immunity
DC Field | Value | Language |
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dc.contributor.author | Lee, Jae-Won | - |
dc.contributor.author | Park, Bum Chul | - |
dc.contributor.author | Jang, Na Yoon | - |
dc.contributor.author | Lee, Sihyeon | - |
dc.contributor.author | Cho, Young Kyu | - |
dc.contributor.author | Sharma, Prashant | - |
dc.contributor.author | Byun, Sang Won | - |
dc.contributor.author | Jeon, Kyeongseok | - |
dc.contributor.author | Jeon, Yun-Hui | - |
dc.contributor.author | Park, Uni | - |
dc.contributor.author | Ro, Hyo Jin | - |
dc.contributor.author | Park, Hyo Ree | - |
dc.contributor.author | Kim, Yuri | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Chung, Seok | - |
dc.contributor.author | Kim, Young Keun | - |
dc.contributor.author | Cho, Nam-Hyuk | - |
dc.date.accessioned | 2022-12-09T10:00:25Z | - |
dc.date.available | 2022-12-09T10:00:25Z | - |
dc.date.created | 2022-12-08 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/146584 | - |
dc.description.abstract | Tertiary lymphoid structures (TLSs) provide specialized niches for immune cells, resulting in improved prognoses for patients undergoing cancer immunotherapy. Shaping TLS-like niches may improve anti-cancer immunity and overcome the current limitations of immune cell-based immunotherapy. Here, it is shown that stromal vascular fraction (SVF) from adipose tissues can enhance dendritic cell (DC)-mediated T cell immunity by inducing ectopic T lymphocyte clusters. SVF cells expanded ex vivo have phenotypes and functions similar to those of fibroblastic reticular cells in a secondary lymphoid organ, and their properties can be modulated using three-dimensional spheroid culture and coculture with DCs spiked with antigen-loaded iron oxide-zinc oxide core-shell nanoparticles. Thereby, the combination of SVF spheroids and mature DCs significantly augments T cell recruitment and retention at the injection site. This strategy elicits enhanced antigen-specific immune response and anti-tumoral immunity in mice, illustrating the potential for a novel immunotherapeutic design using SVF as a structural scaffold for TLS. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | FIBROBLASTIC RETICULAR CELLS | - |
dc.subject | LYMPH-NODES | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | RECEPTOR | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | HOMEOSTASIS | - |
dc.subject | MATURATION | - |
dc.subject | SURVIVAL | - |
dc.title | Inducing Ectopic T Cell Clusters Using Stromal Vascular Fraction Spheroid-Based Immunotherapy to Enhance Anti-Tumor Immunity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young Keun | - |
dc.identifier.doi | 10.1002/advs.202203842 | - |
dc.identifier.scopusid | 2-s2.0-85137325890 | - |
dc.identifier.wosid | 000849588600001 | - |
dc.identifier.bibliographicCitation | ADVANCED SCIENCE, v.9, no.28 | - |
dc.relation.isPartOf | ADVANCED SCIENCE | - |
dc.citation.title | ADVANCED SCIENCE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 28 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | FIBROBLASTIC RETICULAR CELLS | - |
dc.subject.keywordPlus | LYMPH-NODES | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | cancer immunotherapy | - |
dc.subject.keywordAuthor | dendritic cells | - |
dc.subject.keywordAuthor | immunotherapy | - |
dc.subject.keywordAuthor | iron-oxide zinc oxide nanoparticles | - |
dc.subject.keywordAuthor | spheroid | - |
dc.subject.keywordAuthor | stromal vascular fraction | - |
dc.subject.keywordAuthor | tertiary lymphoid structure | - |
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