Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infectionopen access
- Authors
- Jeong, H.W.; Kim, S.-M.; Jung, M.K.; Noh, J.Y.; Yoo, J.-S.; Kim, E.-H.; Kim, Y.-I.; Yu, K.; Jang, S.-G.; Gil, J.; Casel, M.A.; Rare, R.; Choi, J.H.; Kim, H.-S.; Kim, J.H.; Um, J.; Kim, C.; Kim, Y.; Chin, B.S.; Jung, S.; Choi, J.Y.; Song, K.-H.; Kim, Y.-D.; Park, J.-S.; Song, J.Y.; Shin, E.-C.; Choi, Y.K.
- Issue Date
- 2022
- Publisher
- Cell Press
- Keywords
- ancestral; breakthrough infection; cross-neutralization; D614G; mRNA vaccine; Omicron BA.1; Omicron BA.2; recovered patient; SARS-CoV-2; T cell immune response; variants of concern
- Citation
- Cell Reports Medicine, v.3, no.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cell Reports Medicine
- Volume
- 3
- Number
- 10
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/146992
- DOI
- 10.1016/j.xcrm.2022.100764
- ISSN
- 2666-3791
- Abstract
- Omicron has become the globally dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, creating additional challenges due to its ability to evade neutralization. Here, we report that neutralizing antibodies against Omicron variants are undetected following COVID-19 infection with ancestral or past SARS-CoV-2 variant viruses or after two-dose mRNA vaccination. Compared with two-dose vaccination, a three-dose vaccination course induces broad neutralizing antibody responses with improved durability against different SARS-CoV-2 variants, although neutralizing antibody titers against Omicron remain low. Intriguingly, among individuals with three-dose vaccination, Omicron breakthrough infection substantially augments serum neutralizing activity against a broad spectrum of SARS-CoV-2 variants, including Omicron variants BA.1, BA.2, and BA.5. Additionally, after Omicron breakthrough infection, memory T cells respond to the spike proteins of both ancestral and Omicron SARS-CoV-2 by producing cytokines with polyfunctionality. These results suggest that Omicron breakthrough infection following three-dose mRNA vaccination induces pan-SARS-CoV-2 immunity that may protect against emerging SARS-CoV-2 variants of concern. © 2022 The Author(s)
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