De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variants
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, M. | - |
dc.contributor.author | Kang, B. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Jung, S.T. | - |
dc.contributor.author | Son, C.Y. | - |
dc.contributor.author | Oh, S.S. | - |
dc.date.accessioned | 2022-12-11T11:40:55Z | - |
dc.date.available | 2022-12-11T11:40:55Z | - |
dc.date.created | 2022-12-08 | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/146993 | - |
dc.description.abstract | The frequent occurrence of viral variants is a critical problem in developing antiviral prophylaxis and therapy; along with stronger recognition of host cell receptors, the variants evade the immune system-based vaccines and neutralizing agents more easily. In this work, we focus on enhanced receptor binding of viral variants and demonstrate generation of receptor-mimicking synthetic reagents, capable of strongly interacting with viruses and their variants. The hotspot interaction of viruses with receptor-derived short peptides is maximized by aptamer-like scaffolds, the compact and stable architectures of which can be in vitro selected from a myriad of the hotspot peptide-coupled random nucleic acids. We successfully created the human angiotensin-converting enzyme 2 (hACE2) receptor-mimicking hybrid ligand that recruits the hACE2-derived receptor binding domain-interacting peptide to directly interact with a binding hotspot of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Experiencing affinity boosting by ∼500% to Omicron, the de novo selected hACE2 mimic exhibited a great binding tolerance to all SARS-CoV-2 variants of concern. © 2022 The Authors. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variants | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, S.T. | - |
dc.identifier.doi | 10.1126/sciadv.abq6207 | - |
dc.identifier.scopusid | 2-s2.0-85140817643 | - |
dc.identifier.bibliographicCitation | Science Advances, v.8, no.43 | - |
dc.relation.isPartOf | Science Advances | - |
dc.citation.title | Science Advances | - |
dc.citation.volume | 8 | - |
dc.citation.number | 43 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.