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NADPH oxidase inhibitor development for diabetic nephropathy through water tank modelopen access

Authors
Lee, H.E.Shim, S.Choi, Y.Bae, Y.S.
Issue Date
Sep-2022
Publisher
The Korean Society of Nephrology
Keywords
Diabetic nephropathies; NADPH oxidases; Nox inhibitor; Oxidative stress; Reactive oxygen species
Citation
Kidney Research and Clinical Practice, v.41, pp S89 - S98
Indexed
SCIE
SCOPUS
KCI
Journal Title
Kidney Research and Clinical Practice
Volume
41
Start Page
S89
End Page
S98
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/146995
DOI
10.23876/j.krcp.21.269
ISSN
2211-9132
2211-9140
Abstract
Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy. © 2022 by The Korean Society of Nephrology.
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