Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Impaired functional cortical networks in the theta frequency band of patients with post-traumatic stress disorder during auditory-cognitive processingopen access

Authors
Shim, M.Hwang, H.-J.Lee, S.-H.
Issue Date
8월-2022
Publisher
Frontiers Media S.A.
Keywords
cognitive function; electroencephalogram; functional cortical networks; post-traumatic stress disorder (PSTD); theta frequency band
Citation
Frontiers in Psychiatry, v.13
Indexed
SCIE
SSCI
SCOPUS
Journal Title
Frontiers in Psychiatry
Volume
13
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/147024
DOI
10.3389/fpsyt.2022.811766
ISSN
1664-0640
Abstract
Impaired cognitive function related to intrusive memories of traumatic experiences is the most noticeable characteristic of post-traumatic stress disorder (PTSD); nevertheless, the brain mechanism involved in the cognitive processing is still elusive. To improve the understanding of the neuropathology in PTSD patients, we investigated functional cortical networks that are based on graph theory, by using electroencephalogram (EEG). EEG signals, elicited by an auditory oddball paradigm, were recorded from 53 PTSD patients and 39 healthy controls (HCs). Source signals in 68 regions of interests were estimated using EEG data for each subject using minimum-norm estimation. Then, using source signals of each subject, time-frequency analysis was conducted, and a functional connectivity matrix was constructed using the imaginary part of coherence, which was used to evaluate three global-level (strength, clustering coefficient, and path length) and two nodal-level (strength and clustering coefficients) network indices in four frequency bands (theta, alpha, low-beta, and high-beta). The relationships between the network indices and symptoms were evaluated using Pearson’s correlation. Compared with HCs, PTSD patients showed significantly reduced spectral powers around P300 periods and significantly altered network indices (diminished strength and clustering coefficient, and prolonged path length) in theta frequency band. In addition, the nodal strengths and nodal clustering coefficients in theta band of PTSD patients were significantly reduced, compared with those of HCs, and the reduced nodal clustering coefficients in parieto-temporo-occipital regions had negative correlations with the symptom scores (Impact of Event Scale-Revises, Beck Depression Inventory, and Beck Anxiety Inventory). The characterization of this disrupted pattern improves the understanding of the neuropathophysiology underlying the impaired cognitive function in PTSD patients. Copyright © 2022 Shim, Hwang and Lee.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Electronics and Information Engineering > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE