White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
DC Field | Value | Language |
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dc.contributor.author | Byun, Jung-Ick | - |
dc.contributor.author | Oh, Seunghwan | - |
dc.contributor.author | Sunwoo, Jun-Sang | - |
dc.contributor.author | Shin, Jung-Won | - |
dc.contributor.author | Kim, Tae-Joon | - |
dc.contributor.author | Jun, Jin-Sun | - |
dc.contributor.author | Kim, Han-Joon | - |
dc.contributor.author | Shin, Won Chul | - |
dc.contributor.author | Seong, Joon-Kyung | - |
dc.contributor.author | Jung, Ki-Young | - |
dc.date.accessioned | 2022-12-11T22:40:17Z | - |
dc.date.available | 2022-12-11T22:40:17Z | - |
dc.date.created | 2022-12-08 | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2213-1582 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/147101 | - |
dc.description.abstract | Objective: White matter (WM) tract-specific changes may precede gray matter loss in isolated rapid eye movement sleep behavior disorder (iRBD). We aimed to evaluate tract-specific WM changes using tract-specific statistical analysis (TSSA) and their correlation with clinical variables in iRBD patients. Methods: This was a cross-sectional single-center study of 50 polysomnography-confirmed iRBD patients and 20 age-and sex-matched controls. We used TSSA to identify tract-specific fractional anisotropy (FA) and mean diffusivity (MD) in fourteen major fiber tracts and analyzed between-group differences in these values. Corre-lations between FA or MD values and clinical variables, including RBD symptom severity, depression and cognition, were evaluated. Results: Patients with iRBD showed lower FA in the right anterior thalamic radiation (ATR) and higher MD in the bilateral ATR and right inferior fronto-occipital fasciculus (IF-OF) than controls after adjusting for age, sex, and years of education. MD values in the IF-OF positively correlated with scores on the Korean version of the Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong (RBDQ-KR, p = 0.042) and the Korean version of the geriatric depression scale (GDS-K, p = 0.002) in iRBD patients. Only GDS-K scores independently corre-lated with IF-OF MD values after adjusting for RBDQ-KR scores (adjusted p = 0.026). Conclusion: This study suggests WM microstructural disruption in the bilateral ATR and right IF-OF in patients with iRBD and that alterations in the IF-OF may contribute to depressive symptoms. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | SLEEP BEHAVIOR DISORDER | - |
dc.subject | KOREAN VERSION | - |
dc.subject | COGNITIVE IMPAIRMENT | - |
dc.subject | VALIDATION | - |
dc.subject | DEFICITS | - |
dc.subject | VOXEL | - |
dc.title | White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seong, Joon-Kyung | - |
dc.identifier.doi | 10.1016/j.nicl.2022.103186 | - |
dc.identifier.scopusid | 2-s2.0-85138057251 | - |
dc.identifier.wosid | 000861821700001 | - |
dc.identifier.bibliographicCitation | NEUROIMAGE-CLINICAL, v.36 | - |
dc.relation.isPartOf | NEUROIMAGE-CLINICAL | - |
dc.citation.title | NEUROIMAGE-CLINICAL | - |
dc.citation.volume | 36 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neuroimaging | - |
dc.subject.keywordPlus | SLEEP BEHAVIOR DISORDER | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | VOXEL | - |
dc.subject.keywordAuthor | REM sleep behavior disorder | - |
dc.subject.keywordAuthor | Tract-specific statistical analysis | - |
dc.subject.keywordAuthor | Tractography | - |
dc.subject.keywordAuthor | Neuroimaging | - |
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