Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genesopen access
- Authors
- Park, Kyu Hee; Choi, Yoon Ji; Min, Won Kee; Lee, Sun Hwa; Kim, Jaeyoung; Jeong, Sang Hoon; Lee, Ju-Han; Choi, Byung Min; Kim, Suhyun
- Issue Date
- 15-Sep-2023
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Particulate matter; Heart; Arrhythmia; Heavy metal; Ion channel; Zebrafish
- Citation
- ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v.263
- Indexed
- SCIE
SCOPUS
- Journal Title
- ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
- Volume
- 263
- ISSN
- 0147-6513
1090-2414
- Abstract
- Air pollution is a risk factor that increases cardiovascular morbidity and mortality. In this study, we investigated the cardiotoxicity of particulate matter (PM) exposure using a zebrafish embryo model. We found that PM exposure induced cardiotoxicity, such as arrhythmia, during cardiac development. PM exposure caused cardiotoxicity by altering the expression levels of cardiac development (T-box transcription factor 20, natriuretic peptide A, and GATA-binding protein 4)-and ion-channel (scn5lab, kcnq1, kcnh2a/b, and kcnh6a/b)-related genes. In conclusion, this study showed that PM induces the aberrant expression of cardiac development-and ion channel-related genes, leading to arrhythmia-like cardiotoxicity in zebrafish embryos. Our study provides a foundation for further research on the molecular and genetic mechanisms of cardiotoxicity induced by PM exposure.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Lee, Ju Han
- College of Medicine (Department of Medical Science)