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Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes

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dc.contributor.authorPark, Kyu Hee-
dc.contributor.authorChoi, Yoon Ji-
dc.contributor.authorMin, Won Kee-
dc.contributor.authorLee, Sun Hwa-
dc.contributor.authorKim, Jaeyoung-
dc.contributor.authorJeong, Sang Hoon-
dc.contributor.authorLee, Ju-Han-
dc.contributor.authorChoi, Byung Min-
dc.contributor.authorKim, Suhyun-
dc.date.accessioned2024-11-18T02:44:09Z-
dc.date.available2024-11-18T02:44:09Z-
dc.date.issued2023-09-15-
dc.identifier.issn0147-6513-
dc.identifier.issn1090-2414-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/192583-
dc.description.abstractAir pollution is a risk factor that increases cardiovascular morbidity and mortality. In this study, we investigated the cardiotoxicity of particulate matter (PM) exposure using a zebrafish embryo model. We found that PM exposure induced cardiotoxicity, such as arrhythmia, during cardiac development. PM exposure caused cardiotoxicity by altering the expression levels of cardiac development (T-box transcription factor 20, natriuretic peptide A, and GATA-binding protein 4)-and ion-channel (scn5lab, kcnq1, kcnh2a/b, and kcnh6a/b)-related genes. In conclusion, this study showed that PM induces the aberrant expression of cardiac development-and ion channel-related genes, leading to arrhythmia-like cardiotoxicity in zebrafish embryos. Our study provides a foundation for further research on the molecular and genetic mechanisms of cardiotoxicity induced by PM exposure.-
dc.language영어-
dc.language.isoENG-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.titleParticulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1016/j.ecoenv.2023.115201-
dc.identifier.scopusid2-s2.0-85164279461-
dc.identifier.wosid001041108100001-
dc.identifier.bibliographicCitationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v.263-
dc.citation.titleECOTOXICOLOGY AND ENVIRONMENTAL SAFETY-
dc.citation.volume263-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEnvironmental Sciences & Ecology-
dc.relation.journalResearchAreaToxicology-
dc.relation.journalWebOfScienceCategoryEnvironmental Sciences-
dc.relation.journalWebOfScienceCategoryToxicology-
dc.subject.keywordPlusLONG-TERM EXPOSURE-
dc.subject.keywordPlusAIR-POLLUTION-
dc.subject.keywordPlusCARDIOVASCULAR-DISEASE-
dc.subject.keywordPlusMATERNAL EXPOSURE-
dc.subject.keywordPlusTRANSCRIPTION FACTOR-
dc.subject.keywordPlusCHEMICAL-COMPOSITION-
dc.subject.keywordPlusQT-SYNDROME-
dc.subject.keywordPlusPM2.5-
dc.subject.keywordPlusRISK-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordAuthorParticulate matter-
dc.subject.keywordAuthorHeart-
dc.subject.keywordAuthorArrhythmia-
dc.subject.keywordAuthorHeavy metal-
dc.subject.keywordAuthorIon channel-
dc.subject.keywordAuthorZebrafish-
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