Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes
DC Field | Value | Language |
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dc.contributor.author | Park, Kyu Hee | - |
dc.contributor.author | Choi, Yoon Ji | - |
dc.contributor.author | Min, Won Kee | - |
dc.contributor.author | Lee, Sun Hwa | - |
dc.contributor.author | Kim, Jaeyoung | - |
dc.contributor.author | Jeong, Sang Hoon | - |
dc.contributor.author | Lee, Ju-Han | - |
dc.contributor.author | Choi, Byung Min | - |
dc.contributor.author | Kim, Suhyun | - |
dc.date.accessioned | 2024-11-18T02:44:09Z | - |
dc.date.available | 2024-11-18T02:44:09Z | - |
dc.date.issued | 2023-09-15 | - |
dc.identifier.issn | 0147-6513 | - |
dc.identifier.issn | 1090-2414 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/192583 | - |
dc.description.abstract | Air pollution is a risk factor that increases cardiovascular morbidity and mortality. In this study, we investigated the cardiotoxicity of particulate matter (PM) exposure using a zebrafish embryo model. We found that PM exposure induced cardiotoxicity, such as arrhythmia, during cardiac development. PM exposure caused cardiotoxicity by altering the expression levels of cardiac development (T-box transcription factor 20, natriuretic peptide A, and GATA-binding protein 4)-and ion-channel (scn5lab, kcnq1, kcnh2a/b, and kcnh6a/b)-related genes. In conclusion, this study showed that PM induces the aberrant expression of cardiac development-and ion channel-related genes, leading to arrhythmia-like cardiotoxicity in zebrafish embryos. Our study provides a foundation for further research on the molecular and genetic mechanisms of cardiotoxicity induced by PM exposure. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.ecoenv.2023.115201 | - |
dc.identifier.scopusid | 2-s2.0-85164279461 | - |
dc.identifier.wosid | 001041108100001 | - |
dc.identifier.bibliographicCitation | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v.263 | - |
dc.citation.title | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | - |
dc.citation.volume | 263 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | LONG-TERM EXPOSURE | - |
dc.subject.keywordPlus | AIR-POLLUTION | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | MATERNAL EXPOSURE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | CHEMICAL-COMPOSITION | - |
dc.subject.keywordPlus | QT-SYNDROME | - |
dc.subject.keywordPlus | PM2.5 | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordAuthor | Particulate matter | - |
dc.subject.keywordAuthor | Heart | - |
dc.subject.keywordAuthor | Arrhythmia | - |
dc.subject.keywordAuthor | Heavy metal | - |
dc.subject.keywordAuthor | Ion channel | - |
dc.subject.keywordAuthor | Zebrafish | - |
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