Development of Retinol-loaded Polymeric Micelle: Stability of Retinol

Abstract

Retinol is unstable to the external environment and its properties can deteriorate. Therefore, new stabilization techniques for retinol are needed. According to this trend, a lot of research to improve the stability of retinol is ongoing. Antioxidants were added to the core part of the retinol polymeric micelle particle by content. After preparting the retinol micelle formulation with antioxidants by content, experiments such as particle size measurement, long-term and accelerated stability test, and skin permeation were performed. The micelle particle size depended on the antioxidant ratio. The retinol proportion of M3 composition with a ratio of retinol to butylated hydroxyanisole (BHA) of 1:1 did not show any change in both long-term stability test (80.83%) and accelerated stability test (81.18%). Skin permeation experiments were performed on this formulation. As a result, the skin permeability of M3 (52.8%) was greater than that of S1 used as a control. As a comprehensive result, retinol stability was improved by establishing an appropriate ratio of antioxidants and surfactants.