Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder
DC Field | Value | Language |
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dc.contributor.author | Kim, Sun-Young | - |
dc.contributor.author | Kim, Han-Na | - |
dc.contributor.author | Jeon, Sang Won | - |
dc.contributor.author | Lim, Weon-Jeong | - |
dc.contributor.author | Kim, Soo In | - |
dc.contributor.author | Lee, Youn Jung | - |
dc.contributor.author | Kim, Se Young | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.date.accessioned | 2021-08-30T02:44:24Z | - |
dc.date.available | 2021-08-30T02:44:24Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2021-04-20 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49417 | - |
dc.description.abstract | We aimed to investigate the associations between genetic variants of the norepinephrine transporter gene (NET, also known as SLC6A2) and diagnosis of bipolar I disorder. In addition, we examined the relationship between the genetic variants and manic and psychotic symptoms in patients with bipolar I disorder. The three SNPs rs28386840, rs2242446, and rs5569 were genotyped in 326 patients: patients with bipolar I disorder (n = 160) and a control group (n = 166). Subsequently, multivariate logistic regression analysis adjusting for age and sex was conducted to identify independent influences of the SNPs on diagnosis of bipolar I disorder. A possible association between manic and psychotic symptoms and variants of SLC6A2 was also investigated in patients with bipolar I disorder. The rs28836840 SNP in the 5'-UTR of SLC6A2 was significantly associated with bipolar I disorder and with severity of manic and psychotic symptoms in this disorder. Individuals carrying a T allele in the rs28836840 SNP were likely to have a lower risk of bipolar I disorder or lower severity of manic and psychotic symptoms in patients with bipolar I disorder (bipolar I disorder diagnosis: OR = 0.643, 95% Cl = 0.468-0.883, p = 0.006; manic symptoms: beta = -2.457, 95% Cl = -4.674 similar to -0.239, p = 0.031; psychotic symptoms: beta = -2.501, 95% Cl = -4.700 similar to -0.301, p = 0.027). For the rs2242446 and rs5569 SNPs, there were no significant differences between patients with bipolar I disorder and those without. Our results revealed associations of the rs28386840 SNP with bipolar I disorder diagnosis and with severity of manic and psychotic symptoms. However, the findings reported here require replication in larger samples and various ethnic groups. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1016/j.pnpbp.2020.110227 | - |
dc.identifier.scopusid | 2-s2.0-85098163365 | - |
dc.identifier.wosid | 000617280700010 | - |
dc.identifier.bibliographicCitation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.107 | - |
dc.relation.isPartOf | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.title | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.volume | 107 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | BIOCHEMICAL CLASSIFICATION | - |
dc.subject.keywordPlus | MONOAMINE METABOLITES | - |
dc.subject.keywordPlus | DEPRESSIVE-DISORDERS | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | MHPG | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | MANIA | - |
dc.subject.keywordAuthor | Bipolar I disorder | - |
dc.subject.keywordAuthor | SLC6A2 | - |
dc.subject.keywordAuthor | NET | - |
dc.subject.keywordAuthor | Manic symptom | - |
dc.subject.keywordAuthor | Psychotic symptom | - |
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