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Hand-ground fullerene-nanodiamond composite for photosensitized water treatment and photodynamic cancer therapy

Authors
Lee, HongshinLee, Jung SeokMoor, Kyle J.Kim, Hyoung-ilKim, Sang-RyoungGim, GeonduLee, JaesangKim, Hak-HyeonFahmy, Tarek M.Kim, Jae-HongLee, Changha
Issue Date
4월-2021
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Fullerene C-60; Nanodiamond; Singlet oxygen; Water purification; Targeted cancer chemotherapy
Citation
JOURNAL OF COLLOID AND INTERFACE SCIENCE, v.587, pp.101 - 109
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume
587
Start Page
101
End Page
109
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/49441
DOI
10.1016/j.jcis.2020.12.020
ISSN
0021-9797
Abstract
The unique capability of fullerene (C-60) to absorb light and generate reactive oxygen species (ROS) has been extensively studied for photosensitized water treatment and cancer therapy. Various material synthesis strategies have been proposed in parallel to overcome its intrinsic hydrophobicity and to enhance availability in water and physiological media. We present here a strikingly simple approach to make C-60 available to these applications by hand-grinding dry C-60 powder with nanodiamond (ND) using a mortar and pestle. The resulting ND-C-60 composite was found to form a stable aqueous colloidal suspension and efficiently drive photosensitized production of ROS under visible light illumination. ND-C-60 rapidly adsorbed and oxidized organic contaminants by photogenerated ROS. In the experiments for photodynamic cancer therapy, ND-C-60 was internalized by cancer cells and induced cell apoptosis without noticeable toxicity. Treatment of tumor-bearing mice with ND-C-60 and light irradiation resulted in tumor shrinkage and prolonged survival time. (c) 2020 Elsevier Inc. All rights reserved.
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Lee, Jae sang
공과대학 (건축사회환경공학부)
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