Effect of PM10 on pulmonary immune response and fetus development
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Eun-Jung | - |
dc.contributor.author | Yoon, Cheolho | - |
dc.contributor.author | Han, Ji-Seok | - |
dc.contributor.author | Lee, Gwang-Hee | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Park, Eun-Jun | - |
dc.contributor.author | Lim, Hyun-Ji | - |
dc.contributor.author | Kang, Min-Sung | - |
dc.contributor.author | Han, Hyoung-Yun | - |
dc.contributor.author | Seol, Hyun-Joo | - |
dc.contributor.author | Kim, Kwang Pyo | - |
dc.date.accessioned | 2021-08-30T02:49:45Z | - |
dc.date.available | 2021-08-30T02:49:45Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2021-03-15 | - |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49474 | - |
dc.description.abstract | Despite numerous reports that ambient particulate matter is a key determinant for human health, toxicity data produced based on physicochemical properties of particulate matters is very lack, suggesting lack of scientific evidence for regulation. In this study, we sampled inhalable particulate matters (PM10) in northern Seoul, Korea. PM10 showed atypical- and fiber-type particles with the average size and the surface charge of 1,598.1 +/- 128.7 nm and -27.5 +/- 2.8, respectively, and various toxic elements were detected in the water extract. On day 90 after the first pulmonary exposure, total cell number dose-dependently increased in the lungs of both sexes of mice. PM10 induced Th1-dominant immune response with pathological changes in both sexes of mice. Meanwhile, composition of total cells and expression of proteins which functions in cell-to-cell communication showed different trends between sexes. Following, male and female mice were mated to identify effects of PM10 to the next generation. PM10 remained in the lung of dams until day 21 after birth, and the levels of IgA and IgE increased in the blood of dams exposed to the maximum dose compared to control. In addition, the interval between births of fetuses, the number of offspring, the neonatal survival rate (day 4 after birth) and the sex ratio seemed to be affected at the maximum dose, and particularly, all offspring from one dam were stillborn. In addition, expression of HIF-1 alpha protein increased in the lung tissue of dams exposed to PM10, and level of hypoxia-related proteins was notably enhanced in PM10-exposed bronchial epithelial cells compared to control. Taken together, we suggest that inhaled PM10 may induce Th1-shifting immune response in the lung, and that it may affect reproduction (fetus development) by causing lung hypoxia. Additionally, we propose that further study is needed to identify particle-size-dependent effects on development of the next generation. (C) 2020 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | FINE PARTICULATE MATTER | - |
dc.subject | AIR-POLLUTION EXPOSURE | - |
dc.subject | CARBON NANOTUBES | - |
dc.subject | MATERNAL SMOKING | - |
dc.subject | DEFICIENT MICE | - |
dc.subject | NURSES HEALTH | - |
dc.subject | BIRTH-WEIGHT | - |
dc.subject | RISK | - |
dc.subject | IRON | - |
dc.subject | FIBROSIS | - |
dc.title | Effect of PM10 on pulmonary immune response and fetus development | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Gwang-Hee | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.identifier.doi | 10.1016/j.toxlet.2020.11.024 | - |
dc.identifier.scopusid | 2-s2.0-85098519349 | - |
dc.identifier.wosid | 000608184700001 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY LETTERS, v.339, pp.1 - 11 | - |
dc.relation.isPartOf | TOXICOLOGY LETTERS | - |
dc.citation.title | TOXICOLOGY LETTERS | - |
dc.citation.volume | 339 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | FINE PARTICULATE MATTER | - |
dc.subject.keywordPlus | AIR-POLLUTION EXPOSURE | - |
dc.subject.keywordPlus | CARBON NANOTUBES | - |
dc.subject.keywordPlus | MATERNAL SMOKING | - |
dc.subject.keywordPlus | DEFICIENT MICE | - |
dc.subject.keywordPlus | NURSES HEALTH | - |
dc.subject.keywordPlus | BIRTH-WEIGHT | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | IRON | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordAuthor | Air pollution | - |
dc.subject.keywordAuthor | Particulate materials | - |
dc.subject.keywordAuthor | Lung inflammation | - |
dc.subject.keywordAuthor | Interferon gamma | - |
dc.subject.keywordAuthor | Hypoxia | - |
dc.subject.keywordAuthor | Stillbirth | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.