Development of a Ga-68-labelled PET tracer for carbonic anhydrase IX-overexpressed tumors using the artificial sweetener saccharin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Un Chul | - |
dc.contributor.author | Choi, Jeong Su | - |
dc.contributor.author | Beak, Yeon Jae | - |
dc.contributor.author | Lee, Min Woo | - |
dc.contributor.author | Kim, Hyung Soo | - |
dc.contributor.author | Choi, Dal Woong | - |
dc.contributor.author | Kim, Dong Gil | - |
dc.contributor.author | Kim, Suhng Wook | - |
dc.date.accessioned | 2021-08-30T02:52:22Z | - |
dc.date.available | 2021-08-30T02:52:22Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 0362-4803 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49502 | - |
dc.description.abstract | In this study, we developed a saccharin (SAC)-based radiopharmaceutical (Ga-68-NOTA-SAC) and evaluated the possibility of its application as a PET tracer in the diagnosis of carbonic anhydrase IX (CA IX)-overexpressed tumors. We did a water-soluble tetrazolium assay and flow cytometry analysis to identify the cell viability decrease by SAC. The radiochemical purity and stability of Ga-68- NOTA-SAC in human and mouse serum was greater than 98%. The small animal PET image-based radioactivity distribution of all organs decreased over time.Ga-68-NOTA-SAC presented the highest tumor-to-muscle ratio at 90 min post injection (p.i). The growth rates of tumor-to-muscle ratios of Ga-68-NOTA-SAC were 88% at 60 min and 220% at 90 min, compared to 30 min p.i. The potential of Ga-68-NOTA-SAC as a PET tracer is expected to contribute to the diagnostic research on CA IX-overexpressed tumors with the advantages of a relatively simple synthesis method. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | TRANSMEMBRANE | - |
dc.subject | DERIVATIVES | - |
dc.subject | METASTASIS | - |
dc.subject | GROWTH | - |
dc.title | Development of a Ga-68-labelled PET tracer for carbonic anhydrase IX-overexpressed tumors using the artificial sweetener saccharin | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Min Woo | - |
dc.contributor.affiliatedAuthor | Choi, Dal Woong | - |
dc.contributor.affiliatedAuthor | Kim, Suhng Wook | - |
dc.identifier.doi | 10.1002/jlcr.3893 | - |
dc.identifier.scopusid | 2-s2.0-85096793419 | - |
dc.identifier.wosid | 000587638800001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, v.64, no.3, pp.129 - 139 | - |
dc.relation.isPartOf | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | - |
dc.citation.title | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | - |
dc.citation.volume | 64 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 129 | - |
dc.citation.endPage | 139 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | TRANSMEMBRANE | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Ga-68& | - |
dc.subject.keywordAuthor | #8208 | - |
dc.subject.keywordAuthor | NOTA& | - |
dc.subject.keywordAuthor | #8208 | - |
dc.subject.keywordAuthor | SAC | - |
dc.subject.keywordAuthor | Carbonic anhydrase IX | - |
dc.subject.keywordAuthor | PET tracer | - |
dc.subject.keywordAuthor | Saccharin | - |
dc.subject.keywordAuthor | U87MG | - |
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