Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea
DC Field | Value | Language |
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dc.contributor.author | Ryou, Sangmi | - |
dc.contributor.author | Yoo, Myeongsu | - |
dc.contributor.author | Kim, Kisoon | - |
dc.contributor.author | Kim, Sangsoo | - |
dc.contributor.author | Kim, Sang Il | - |
dc.contributor.author | Kim, Youn Jeong | - |
dc.contributor.author | Park, Dae Won | - |
dc.contributor.author | Choi, Jun Yong | - |
dc.contributor.author | Kim, Hyo Youl | - |
dc.contributor.author | Kim, Jung Ho | - |
dc.contributor.author | Song, Joon Young | - |
dc.contributor.author | Kim, Shin-Woo | - |
dc.contributor.author | Chang, Hyun-Ha | - |
dc.contributor.author | Choi, Bo Youl | - |
dc.contributor.author | Kee, Mee-Kyung | - |
dc.date.accessioned | 2021-08-30T02:57:48Z | - |
dc.date.available | 2021-08-30T02:57:48Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2021-02-18 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49560 | - |
dc.description.abstract | In Korea, subtype B is the predominant variant of HIV-1, but full genome sequencing and analysis of its viral variants are lacking. We performed near full-length genome (NFLG) sequencing and phylogenetic and recombination analyses of fifty plasma samples from HIV-positive men who have sex with men (MSM) from a Korea HIV/AIDS cohort study. Viral genomes were amplified and the near-full-length sequences were determined using next-generation sequencing (NGS) and Sanger sequencing. We focused on the HIV-1 subtype classification and identification of HIV recombinants. Twelve HIV-1 NFLGs were determined: ten were subtyped as pure HIV-1 subtype B and two recombinant strains as a common subtype CRF07_BC, and a novel subtype CRF43_02G recombined with CRF02_AG again, or a new CRF02_AG and subtype G recombinant. For the ten NFLGs determined by NGS, "the novel recombinant emerged at approximately 2003 and the other nine subtype B about 2004 or 2005". This is the first report analyzing HIV-1 NFLG, including recombinants and clinical characteristics, by subtype among MSM in Korea. Our results provide novel insights for understanding the recombinants in the HIV-1 epidemic in Korea. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Dae Won | - |
dc.contributor.affiliatedAuthor | Song, Joon Young | - |
dc.identifier.doi | 10.1038/s41598-021-82872-3 | - |
dc.identifier.scopusid | 2-s2.0-85101227206 | - |
dc.identifier.wosid | 000621416100017 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MOLECULAR PHYLOGENETIC ANALYSIS | - |
dc.subject.keywordPlus | MOSAIC STRUCTURE | - |
dc.subject.keywordPlus | SAUDI-ARABIA | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordPlus | SEQUENCES | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | AMPLIFICATION | - |
dc.subject.keywordPlus | POPULATION | - |
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