Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Hyeijung | - |
dc.contributor.author | Yang, Soo Hyun | - |
dc.contributor.author | Kim, Jin Yong | - |
dc.contributor.author | Yang, Esther | - |
dc.contributor.author | Park, Hyung Sun | - |
dc.contributor.author | Lee, Se Jeong | - |
dc.contributor.author | Rhyu, Im Joo | - |
dc.contributor.author | Turecki, Gustavo | - |
dc.contributor.author | Lee, Hyun Woo | - |
dc.contributor.author | Kim, Hyun | - |
dc.date.accessioned | 2021-08-30T03:00:22Z | - |
dc.date.available | 2021-08-30T03:00:22Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-02-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49588 | - |
dc.description.abstract | Calcium-dependent secretion activator 2 (CAPS2) regulates the trafficking and exocytosis of neuropeptide-containing dense-core vesicles (DCVs). CAPS2 is prominently expressed in the medial habenula (MHb), which is related to depressive behavior; however, how MHb neurons cause depressive symptoms and the role of CAPS2 remains unclear. We hypothesized that dysfunction of MHb CAPS neurons might cause defects in neuropeptide secretion and the activity of monoaminergic centers, resulting in depressive-like behaviors. In this study, we examined (1) CAPS2 expression in the habenula of depression animal models and major depressive disorder patients and (2) the effects of down-regulation of MHb CAPS2 on the animal behaviors, synaptic transmission in the interpeduncular nucleus (IPN), and neuronal activity of monoamine centers. Habenular CAPS2 expression was decreased in the rat chronic restraint stress model, mouse learned helplessness model, and showed tendency to decrease in depression patients who died by suicide. Knockdown of CAPS2 in the mouse habenula evoked despair-like behavior and a reduction of the release of DCVs in the IPN. Neuronal activity of IPN and monoaminergic centers was also reduced. These results implicate MHb CAPS2 as playing a pivotal role in depressive behavior through the regulation of neuropeptide secretion of the MHb-IPN pathway and the activity of monoaminergic centers. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.identifier.doi | 10.1038/s41598-021-83310-0 | - |
dc.identifier.scopusid | 2-s2.0-85101017202 | - |
dc.identifier.wosid | 000620249300009 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.