Chromatin accessibility of circulating CD8(+) T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Kim, Gwanghun | - |
dc.contributor.author | Kim, Sangjib | - |
dc.contributor.author | Sim, Ji Hyun | - |
dc.contributor.author | Choi, Jiyeob | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Kwon, Minsuk | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Cho, Seung Woo | - |
dc.contributor.author | Kim, Seung Tae | - |
dc.contributor.author | Lee, Jeeyun | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.date.accessioned | 2021-08-30T03:00:30Z | - |
dc.date.available | 2021-08-30T03:00:30Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-02-12 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49589 | - |
dc.description.abstract | Although tumor genomic profiling has identified small subsets of gastric cancer (GC) patients with clinical benefit from anti-PD-1 treatment, not all responses can be explained by tumor sequencing alone. We investigate epigenetic elements responsible for the differential response to anti-PD-1 therapy by quantitatively assessing the genome-wide chromatin accessibility of circulating CD8(+) T cells in patients' peripheral blood. Using an assay for transposase-accessible chromatin using sequencing (ATAC-seq), we identify unique open regions of chromatin that significantly distinguish anti-PD-1 therapy responders from non-responders. GC patients with high chromatin openness of circulating CD8(+) T cells are significantly enriched in the responder group. Concordantly, patients with high chromatin openness at specific genomic positions of their circulating CD8(+) T cells demonstrate significantly better survival than those with closed chromatin. Here we reveal that epigenetic characteristics of baseline CD8(+) T cells can be used to identify metastatic GC patients who may benefit from anti-PD-1 therapy. Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8(+) T cells predicts treatment outcome in patients with metastatic gastric cancer treated with pembrolizumab. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Chromatin accessibility of circulating CD8(+) T cells predicts treatment response to PD-1 blockade in patients with gastric cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sangjib | - |
dc.identifier.doi | 10.1038/s41467-021-21299-w | - |
dc.identifier.scopusid | 2-s2.0-85100853990 | - |
dc.identifier.wosid | 000620683400003 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.12, no.1 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
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