Continuous-flow Si-H functionalizations of hydrosilanes via sequential organolithium reactions catalyzed by potassium tert-butoxide
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyune-Jea | - |
dc.contributor.author | Kwak, Changmo | - |
dc.contributor.author | Kim, Dong-Pyo | - |
dc.contributor.author | Kim, Heejin | - |
dc.date.accessioned | 2021-08-30T03:01:31Z | - |
dc.date.available | 2021-08-30T03:01:31Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-02-07 | - |
dc.identifier.issn | 1463-9262 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49599 | - |
dc.description.abstract | We herein report an atom-economic flow approach to the selective and sequential mono-, di-, and tri-functionalizations of unactivated hydrosilanes via serial organolithium reactions catalyzed by earth-abundant metal compounds. Based on the screening of various additives, we found that catalytic potassium tert-butoxide (t-BuOK) facilitates the rapid reaction of organolithiums with hydrosilanes. Using a flow microreactor system, various organolithiums bearing functional groups were efficiently generated in situ under mild conditions and consecutively reacted with hydrosilanes in the presence of t-BuOK within 1 min. We also successfully conducted the di-funtionalizations of dihydrosilane by sequential organolithium reactions, extending to a gram-scale-synthesis. Finally, the combinatorial functionalizations of trihydrosilane were achieved to give every conceivable combination of tetrasubstituted organosilane libraries based on a precise reaction control using an integrated one-flow system. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Continuous-flow Si-H functionalizations of hydrosilanes via sequential organolithium reactions catalyzed by potassium tert-butoxide | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Heejin | - |
dc.identifier.doi | 10.1039/d0gc03213a | - |
dc.identifier.scopusid | 2-s2.0-85101071982 | - |
dc.identifier.wosid | 000618044800033 | - |
dc.identifier.bibliographicCitation | GREEN CHEMISTRY, v.23, no.3, pp.1193 - 1199 | - |
dc.relation.isPartOf | GREEN CHEMISTRY | - |
dc.citation.title | GREEN CHEMISTRY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1193 | - |
dc.citation.endPage | 1199 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Green & Sustainable Science & Technology | - |
dc.subject.keywordPlus | SERIAL MICROREACTIONS | - |
dc.subject.keywordPlus | AROMATIC HETEROCYCLES | - |
dc.subject.keywordPlus | SILYLATION | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | ARENES | - |
dc.subject.keywordPlus | REARRANGEMENT | - |
dc.subject.keywordPlus | HETEROARENES | - |
dc.subject.keywordPlus | REACTIVITY | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | LIGAND | - |
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