Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device
- Authors
- Kim, Jaehoon; Yoon, Junghyo; Byun, Jae-Yeong; Kim, Hyunho; Han, Sewoon; Kim, Junghyun; Lee, Jeong Hoon; Jo, Han-Sang; Chung, Seok
- Issue Date
- 2월-2021
- Publisher
- MDPI
- Keywords
- microfluidics; point-of-care testing; blood plasma extraction
- Citation
- SENSORS, v.21, no.4, pp.1 - 19
- Indexed
- SCIE
SCOPUS
- Journal Title
- SENSORS
- Volume
- 21
- Number
- 4
- Start Page
- 1
- End Page
- 19
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/49648
- DOI
- 10.3390/s21041366
- ISSN
- 1424-8220
- Abstract
- Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 mu L of extracted plasma with a high extraction yield (similar to 45%) in 16 min.
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Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
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