Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeom, Eunbyul | - |
dc.contributor.author | Shin, Hyemi | - |
dc.contributor.author | Yoo, Wonbeak | - |
dc.contributor.author | Jun, Eunsung | - |
dc.contributor.author | Kim, Seokho | - |
dc.contributor.author | Hong, Seung Hyun | - |
dc.contributor.author | Kwon, Dae-Woo | - |
dc.contributor.author | Ryu, Tae Hoon | - |
dc.contributor.author | Suh, Jae Myoung | - |
dc.contributor.author | Kim, Song Cheol | - |
dc.contributor.author | Lee, Kyu-Sun | - |
dc.contributor.author | Yu, Kweon | - |
dc.date.accessioned | 2021-08-30T03:28:31Z | - |
dc.date.available | 2021-08-30T03:28:31Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 1465-7392 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49659 | - |
dc.description.abstract | In patients with advanced-stage cancer, cancer-associated anorexia affects treatment success and patient survival. However, the underlying mechanism is poorly understood. Here, we show that Dilp8, a Drosophila homologue of mammalian insulin-like 3 peptide (INSL3), is secreted from tumour tissues and induces anorexia through the Lgr3 receptor in the brain. Activated Dilp8-Lgr3 signalling upregulated anorexigenic nucleobinding 1 (NUCB1) and downregulated orexigenic short neuropeptide F (sNPF) and NPF expression in the brain. In the cancer condition, the protein expression of Lgr3 and NUCB1 was significantly upregulated in neurons expressing sNPF and NPF. INSL3 levels were increased in tumour-implanted mice and INSL3-treated mouse hypothalamic cells showed Nucb2 upregulation and Npy downregulation. Food consumption was significantly reduced in intracerebrospinal INSL3-injected mice. In patients with pancreatic cancer, higher serum INSL3 levels increased anorexia. These results indicate that tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding hormones through the Lgr3/Lgr8 receptor in Drosophila and mammals. Yeom et al. demonstrate that tumour cell-secreted Dilp8/INSL3 activates Lgr3 signalling and modulates expression of distinct feeding hormones such as NUCB1 and sNPF, thereby inducing anorexia in cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yeom, Eunbyul | - |
dc.identifier.doi | 10.1038/s41556-020-00628-z | - |
dc.identifier.scopusid | 2-s2.0-85100609511 | - |
dc.identifier.wosid | 000616056100002 | - |
dc.identifier.bibliographicCitation | NATURE CELL BIOLOGY, v.23, no.2, pp.172 - + | - |
dc.relation.isPartOf | NATURE CELL BIOLOGY | - |
dc.citation.title | NATURE CELL BIOLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.