Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer
DC Field | Value | Language |
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dc.contributor.author | Bae, Hyocheol | - |
dc.contributor.author | Lee, Jin-Young | - |
dc.contributor.author | Song, Jisoo | - |
dc.contributor.author | Song, Gwonhwa | - |
dc.contributor.author | Lim, Whasun | - |
dc.date.accessioned | 2021-08-30T03:28:54Z | - |
dc.date.available | 2021-08-30T03:28:54Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/49663 | - |
dc.description.abstract | Osthole is a natural coumarin found in a variety of plants and has been reported to have diverse biological functions, including antimicrobial, antiviral, immunomodulatory, and anticancer effects. Here, we investigated the natural derivative osthole as a promising anticancer compound against ovarian cancer and evaluated its ability to suppress and abrogate tumor progression. In addition, we found the endoplasmic reticulum-mitochondrial axis-mediated anticancer mechanisms of osthole against ES2 and OV90 ovarian cancer cells and demonstrated its calcium-dependent pharmacological potential. Mechanistically, osthole was found to target the phosphatidylinositol 3-kinase/mitogen-activated protein kinase signaling pathway to facilitate tumor suppression in ovarian cancer. Furthermore, we identified the effects of osthole in a three-dimensional tumor-formation model using the zebrafish xenograft assay, providing convincing evidence of the pharmacological effects of osthole within the anchorage-independent tumor microenvironment. These findings suggest that osthole has strong potential as a pharmacological agent for targeting ovarian cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | CNIDIUM-MONNIERI | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | GLIOMA-CELLS | - |
dc.subject | ULK1 | - |
dc.subject | APOPTOSIS | - |
dc.subject | TUMORIGENESIS | - |
dc.subject | INHIBITION | - |
dc.subject | PI3K/AKT | - |
dc.subject | CALCIUM | - |
dc.subject | COMPLEX | - |
dc.title | Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwonhwa | - |
dc.identifier.doi | 10.1002/jcp.29913 | - |
dc.identifier.scopusid | 2-s2.0-85088317267 | - |
dc.identifier.wosid | 000550897400001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR PHYSIOLOGY, v.236, no.2, pp.1025 - 1042 | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.title | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.volume | 236 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1025 | - |
dc.citation.endPage | 1042 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | CNIDIUM-MONNIERI | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | GLIOMA-CELLS | - |
dc.subject.keywordPlus | ULK1 | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | TUMORIGENESIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PI3K/AKT | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | calcium homeostasis | - |
dc.subject.keywordAuthor | osthole | - |
dc.subject.keywordAuthor | ovarian cancer | - |
dc.subject.keywordAuthor | zebrafish | - |
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