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The Wound Healing Peptide, AES16-2M, Ameliorates Atopic Dermatitis In Vivo

Authors
Kim, Myun SooSong, JisunPark, SunyoungKim, Tae SungPark, Hyun JeongCho, Daeho
Issue Date
2월-2021
Publisher
MDPI
Keywords
short peptide; AES16-2M; atopic dermatitis
Citation
MOLECULES, v.26, no.4
Indexed
SCIE
SCOPUS
Journal Title
MOLECULES
Volume
26
Number
4
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/49664
DOI
10.3390/molecules26041168
ISSN
1420-3049
Abstract
Peptide materials have recently been considered for use in various industrial fields. Because of their efficacy, safety, and low cost, therapeutic peptides are studied for various diseases, including atopic dermatitis (AD). AD is a common inflammatory skin disease impairing the patient's quality of life. Various therapies, such as treatments with corticosteroids, calcineurin inhibitors, and antibody drugs, have been applied, but numerous side effects have been reported, including skin atrophy, burning, and infection. In the case of antibody drugs, immunogenicity against the drugs can be a problem. To overcome these side effects, small peptides are considered therapeutic agents. We previously identified the small wound healing peptide AES16-2M with a sequence of REGRT, and examined its effects on AD in this study. Interestingly, the administration of AES16-2M downregulated the AD disease score, ear thickness, serum IgE, and thymic stromal lymphopoietin (TSLP) in AD mice. The thickness of the epidermal layer was also improved by AES16-2M treatment. In addition, quantities of IL-4-, IL-13-, and IL-17-producing CD4 T cells from peripheral lymph nodes and spleens were reduced by injection of AES16-2M. Furthermore, the expression of TSLP was significantly reduced in AES16-2M-treated human keratinocytes. Therefore, these results suggest that AES16-2M can be a novel candidate for AD treatment.
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