Antiviral activity of lambda-carrageenan against influenza viruses and severe acute respiratory syndrome coronavirus 2
DC Field | Value | Language |
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dc.contributor.author | Jang, Yejin | - |
dc.contributor.author | Shin, Heegwon | - |
dc.contributor.author | Lee, Myoung Kyu | - |
dc.contributor.author | Kwon, Oh Seung | - |
dc.contributor.author | Shin, Jin Soo | - |
dc.contributor.author | Kim, Yong-il | - |
dc.contributor.author | Kim, Chan Woo | - |
dc.contributor.author | Lee, Hye-Ra | - |
dc.contributor.author | Kim, Meehyein | - |
dc.date.accessioned | 2021-08-30T04:23:29Z | - |
dc.date.available | 2021-08-30T04:23:29Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-01-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50124 | - |
dc.description.abstract | Influenza virus and coronavirus, belonging to enveloped RNA viruses, are major causes of human respiratory diseases. The aim of this study was to investigate the broad spectrum antiviral activity of a naturally existing sulfated polysaccharide, lambda-carrageenan (lambda-CGN), purified from marine red algae. Cell culture-based assays revealed that the macromolecule efficiently inhibited both influenza A and B viruses with EC50 values ranging from 0.3 to 1.4 mu g/ml, as well as currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with an EC50 value of 0.9 +/- 1.1 mu g/ml. No toxicity to the host cells was observed at concentrations up to 300 mu g/ml. Plaque titration and western blot analysis verified that lambda-CGN reduced expression of viral proteins in cell lysates and suppressed progeny virus production in culture supernatants in a dose-dependent manner. This polyanionic compound exerts antiviral activity by targeting viral attachment to cell surface receptors and preventing virus entry. Moreover, its intranasal administration to mice during influenza A viral challenge not only alleviated infection-mediated reductions in body weight but also protected 60% of mice from virus-induced mortality. Thus, lambda-CGN could be a promising antiviral agent for preventing infection with several respiratory viruses. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Antiviral activity of lambda-carrageenan against influenza viruses and severe acute respiratory syndrome coronavirus 2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Ra | - |
dc.identifier.doi | 10.1038/s41598-020-80896-9 | - |
dc.identifier.scopusid | 2-s2.0-85099188961 | - |
dc.identifier.wosid | 000621921500001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | POLY(SODIUM 4-STYRENE SULFONATE) | - |
dc.subject.keywordPlus | SULFATED POLYSACCHARIDES | - |
dc.subject.keywordPlus | IOTA-CARRAGEENAN | - |
dc.subject.keywordPlus | DENGUE VIRUS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | GEL | - |
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