Optimization of a simulated-moving-bed process for continuous separation of racemic and meso-2,3-butanediol using an efficient optimization tool based on nonlinear standing-wave-design method
DC Field | Value | Language |
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dc.contributor.author | Lee, Chung-Gi | - |
dc.contributor.author | Jo, Cheol Yeon | - |
dc.contributor.author | Lee, Ki Bong | - |
dc.contributor.author | Mun, Sungyong | - |
dc.date.accessioned | 2021-08-30T04:29:58Z | - |
dc.date.available | 2021-08-30T04:29:58Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-01-01 | - |
dc.identifier.issn | 1383-5866 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50180 | - |
dc.description.abstract | The feasibility of using a simulated-moving-bed (SMB) process for continuous-mode separation of biotechnologically produced 2,3-butanediol (BD) into racemic-BD and meso-BD has been verified recently. One of the important tasks for facilitating the industrial application of such a BD-isomer separation SMB is to make a substantial improvement in its production rate and/or productivity while meeting the requirements on BD-isomer purities and pressure drop. To address this issue, the comprehensive optimization for a BD-isomer separation SMB was attempted in this study. First, an efficient SMB optimization tool based on a Langmuir isotherm standing-wave-design method was prepared and then applied to comprehensively optimizing the operation and system parameters of the considered SMB. The results revealed that the production rate (Prate), under a given column length, could reach its maximum when feed concentration (C-feed,C-BD) was selected at the one where the negative effect of nonlinearity increase on Prate could be balanced with the positive effect of C-feed,C- BD increase on Prate. The Prate could be improved further by modulating column length (L-c) to be a little lager than the Lc leading to a maximum in feed flow rate (Q(feed)), which was effective in increasing C-feed,C- BD high enough to outweigh the resultant decrease of Q(feed). It was also found that the productivity (Prod) could be enhanced by adopting the L-c smaller than that for a maximum in Q(feed), which could allow a sufficiently large savings of adsorbent to outweigh the resultant decrease of Q(feed) and C-feed,C-BD. Finally, it was confirmed that the comprehensively optimized SMB in this study could lead to more than 17 times the Prate and Prod, compared to the previously reported BD-isomer separation SMB. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | MASS-TRANSFER | - |
dc.subject | SMB | - |
dc.subject | CHROMATOGRAPHY | - |
dc.subject | MIXTURES | - |
dc.subject | SYSTEMS | - |
dc.subject | REACTOR | - |
dc.title | Optimization of a simulated-moving-bed process for continuous separation of racemic and meso-2,3-butanediol using an efficient optimization tool based on nonlinear standing-wave-design method | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Bong | - |
dc.identifier.doi | 10.1016/j.seppur.2020.117597 | - |
dc.identifier.scopusid | 2-s2.0-85089835226 | - |
dc.identifier.wosid | 000580404400055 | - |
dc.identifier.bibliographicCitation | SEPARATION AND PURIFICATION TECHNOLOGY, v.254 | - |
dc.relation.isPartOf | SEPARATION AND PURIFICATION TECHNOLOGY | - |
dc.citation.title | SEPARATION AND PURIFICATION TECHNOLOGY | - |
dc.citation.volume | 254 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | MASS-TRANSFER | - |
dc.subject.keywordPlus | SMB | - |
dc.subject.keywordPlus | CHROMATOGRAPHY | - |
dc.subject.keywordPlus | MIXTURES | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | REACTOR | - |
dc.subject.keywordAuthor | Simulated moving bed | - |
dc.subject.keywordAuthor | Standing wave design | - |
dc.subject.keywordAuthor | racemic-2,3-Butanediol | - |
dc.subject.keywordAuthor | meso-2,3-Butanediol | - |
dc.subject.keywordAuthor | Continuous separation | - |
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