Lactoferrin-Anchored Tannylated Mesoporous Silica Nanomaterials for Enhanced Osteo-Differentiation Ability
DC Field | Value | Language |
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dc.contributor.author | Noh, Sung Hyun | - |
dc.contributor.author | Jo, Han-Saem | - |
dc.contributor.author | Choi, Somang | - |
dc.contributor.author | Song, Hee Gyeong | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Kim, Keung Nyun | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.date.accessioned | 2021-08-30T04:34:44Z | - |
dc.date.available | 2021-08-30T04:34:44Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50224 | - |
dc.description.abstract | In the present study, we created lactoferrin-anchored mesoporous silica nanomaterials with absorbed tannic acid (LF/TA-MSNs) and evaluated the effect of these LF/TA-MSNs on the in vitro osteo-differentiation ability of adipose-derived stem cells (ADSCs) by testing alkaline phosphatase (ALP) level, calcium accumulation, and expression of osteo-differentiation-specific genes, including osteocalcin (OCN) and osteopontin (OPN). Both bare MSNs and LF/TA-MSNs exhibited round nano-particle structures. The LF/TA-MSNs demonstrated prolonged LF release for up to 28 days. Treatment of ADSCs with LF (50 mu g)/TA-MSNs resulted in markedly higher ALP level and calcium accumulation compared to treatment with LF (10 mu g)/TA-MSNs or bare MSNs. Furthermore, LF (50 mu g)/TA-MSNs remarkably increased mRNA levels of osteo-differentiation-specific genes, including OCN and OPN, compared to MSNs or LF (10 mu g)/TA-MSNs. Together, these data suggest that the ability of LF/TA-MSNs to enhance osteo-differentiation of ADSCs make them a possible nanovehicle for bone healing and bone regeneration in patients with bone defect or disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Lactoferrin-Anchored Tannylated Mesoporous Silica Nanomaterials for Enhanced Osteo-Differentiation Ability | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.identifier.doi | 10.3390/pharmaceutics13010030 | - |
dc.identifier.scopusid | 2-s2.0-85099961566 | - |
dc.identifier.wosid | 000610685000001 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, v.13, no.1, pp.1 - 13 | - |
dc.relation.isPartOf | PHARMACEUTICS | - |
dc.citation.title | PHARMACEUTICS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordAuthor | mesoporous silica nanomaterials | - |
dc.subject.keywordAuthor | lactoferrin | - |
dc.subject.keywordAuthor | adipose-derived stem cells | - |
dc.subject.keywordAuthor | osteo-differentiation ability | - |
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