In vivoassessment of the toxicity of electronic cigarettes to zebrafish (Danio rerio) embryos, following gestational exposure, in terms of mortality, developmental toxicity, and hair cell damage: Toxicity of E-cigs to zebrafish embryos
DC Field | Value | Language |
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dc.contributor.author | Chang, Y. S. | - |
dc.contributor.author | Park, S. M. | - |
dc.contributor.author | Rah, Y. C. | - |
dc.contributor.author | Han, E. J. | - |
dc.contributor.author | Koun, S., I | - |
dc.contributor.author | Chang, J. | - |
dc.contributor.author | Choi, J. | - |
dc.date.accessioned | 2021-08-30T04:39:48Z | - |
dc.date.available | 2021-08-30T04:39:48Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0960-3271 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50280 | - |
dc.description.abstract | With the ban of conventional cigarettes from public spaces, electronic cigarette (E-cig) liquids have emerged as a nicotine replacement treatment for smoking cessation. However, consumers possess little knowledge of the ingredients and health effects of E-cig liquids following exposure. This study evaluated hair cell damage and developmental toxicities following gestational exposure to E-cig liquids. Zebrafish embryos were exposed to E-cig liquids at different concentrations (0.1%, 0.2%, and 0.4%). Embryonic developmental toxicity and hair cell damage was evaluated at 6 and 7 d, respectively, after fertilization. The average number of hair cells in the anterior lateral line (ALL) and posterior lateral line (PLL) following E-cig exposure was compared to that of the control. Morphological abnormalities and heart rate were evaluated. E-cig liquids significantly damaged the hair cells in the ALL, compared to the control (control; 52.85 +/- 5.29 cells, 0.1% E-cig; 49.43 +/- 7.70 cells, 0.2% E-cig; 40.68 +/- 12.00 cells, 0.4% E-cig; 32.14 +/- 20.75%; n = 29-40; p < 0.01). At high concentrations, E-cig liquids significantly damaged the hair cells in the PLL (control; 36.88 +/- 5.43 cells, 0.1% E-cig; 33.06 +/- 5.21 cells, 0.2% E-cig; 30.95 +/- 8.03 cells, 0.4% E-cig; 23.72 +/- 15.53%, n = 29-40; p < 0.01). No morphological abnormalities in body shape, somites, notochord, tail, and pectoral fin were observed; however, abnormalities were observed in the dorsal fin and heart rate at high concentrations. Thus, gestational exposure to E-cigs significantly damaged hair cells in a concentration-dependent manner and induced developmental toxicities to the dorsal fin and heart rate at high concentrations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | LATERAL-LINE | - |
dc.subject | PROTECTIVE ROLE | - |
dc.subject | EMBRYOTOXICITY | - |
dc.subject | PREGNANCY | - |
dc.subject | CHEMICALS | - |
dc.subject | PRODUCTS | - |
dc.subject | TOBACCO | - |
dc.subject | SCREEN | - |
dc.subject | MODEL | - |
dc.title | In vivoassessment of the toxicity of electronic cigarettes to zebrafish (Danio rerio) embryos, following gestational exposure, in terms of mortality, developmental toxicity, and hair cell damage: Toxicity of E-cigs to zebrafish embryos | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, J. | - |
dc.identifier.doi | 10.1177/0960327120947785 | - |
dc.identifier.scopusid | 2-s2.0-85089254468 | - |
dc.identifier.wosid | 000558316600001 | - |
dc.identifier.bibliographicCitation | HUMAN & EXPERIMENTAL TOXICOLOGY, v.40, no.1, pp.148 - 157 | - |
dc.relation.isPartOf | HUMAN & EXPERIMENTAL TOXICOLOGY | - |
dc.citation.title | HUMAN & EXPERIMENTAL TOXICOLOGY | - |
dc.citation.volume | 40 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 148 | - |
dc.citation.endPage | 157 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | LATERAL-LINE | - |
dc.subject.keywordPlus | PROTECTIVE ROLE | - |
dc.subject.keywordPlus | EMBRYOTOXICITY | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | CHEMICALS | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | TOBACCO | - |
dc.subject.keywordPlus | SCREEN | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Electronic cigarettes | - |
dc.subject.keywordAuthor | toxicity | - |
dc.subject.keywordAuthor | zebrafish | - |
dc.subject.keywordAuthor | hair cell | - |
dc.subject.keywordAuthor | embryonic development | - |
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