Ferroptosis-Related Genes in Neurodevelopment and Central Nervous System

Abstract

Simple Summary Ferroptosis is a recently defined form of regulatory cell death. To get a grasp of the prospective role of ferroptosis in the brain development, we collated ferroptosis-related genes and investigated their involvement underlying the ferroptosis mechanism and the association with neurological disorders. With the application of ferroptosis as a therapeutic intervention target for such diseases garnering attention, we assume that understanding the genetic architecture of ferroptosis is indispensable. Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.