The Association between Serum Hemoglobin and Renal Prognosis of IgA Nephropathy
DC Field | Value | Language |
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dc.contributor.author | Oh, Tae Ryom | - |
dc.contributor.author | Song, Su Hyun | - |
dc.contributor.author | Choi, Hong Sang | - |
dc.contributor.author | Kim, Chang Seong | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Kang, Kyung Pyo | - |
dc.contributor.author | Kwon, Young Joo | - |
dc.contributor.author | Kim, Soo Wan | - |
dc.contributor.author | Ma, Seong Kwon | - |
dc.contributor.author | Bae, Eun Hui | - |
dc.date.accessioned | 2021-08-30T04:40:39Z | - |
dc.date.available | 2021-08-30T04:40:39Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50289 | - |
dc.description.abstract | Immunoglobin A (IgA) nephropathy causes chronic kidney disease worldwide. Therefore, identifying risk factors associated with the progression of IgA nephropathy is crucial. Anemia is a common complication of chronic kidney disease; however, few studies have investigated the effect of serum hemoglobin on the renal prognosis of IgA nephropathy. This study aimed to determine the effect of serum hemoglobin on the progression of IgA nephropathy. We retrospectively analyzed 4326 patients with biopsy-proven IgA nephropathy. We evaluated the effect of serum hemoglobin on IgA nephropathy progression using Kaplan-Meier survival analyses, the log-rank test, and the Cox proportional hazards model. The primary end-point was progression of IgA nephropathy, defined as dialysis initiation or kidney transplantation. Serum hemoglobin showed a nonlinear relationship with the progression of IgA nephropathy. The Cox proportional hazards model showed that the risk of progression of IgA nephropathy decreased 0.87 times for every 1.0 g/dL increase in serum hemoglobin. In subgroup analyses, reduced serum hemoglobin was an independent risk factor for IgA nephropathy progression only in women. There was no statistically significant interaction of serum hemoglobin between men and women (P-interaction = 0.177). Results of Sensitivity analysis were robust and consistent. Serum hemoglobin at diagnosis was an independent predictor for IgA nephropathy progression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | The Association between Serum Hemoglobin and Renal Prognosis of IgA Nephropathy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Young Joo | - |
dc.identifier.doi | 10.3390/jcm10020363 | - |
dc.identifier.scopusid | 2-s2.0-85106222548 | - |
dc.identifier.wosid | 000611293900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.10, no.2, pp.1 - 11 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordAuthor | glomerulonephritis | - |
dc.subject.keywordAuthor | IgA nephropathy | - |
dc.subject.keywordAuthor | hemoglobin | - |
dc.subject.keywordAuthor | anemia | - |
dc.subject.keywordAuthor | risk factors | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | disease progression | - |
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