Fluoroquinolone Can Be an Effective Treatment Option for Acute Pyelonephritis When the Minimum Inhibitory Concentration of Levofloxacin for the Causative Escherichia coli Is <= 16 mg/L
- Authors
- Kim, Yeonjae; Kim, Bongyoung; Wie, Seong Heon; Kim, Jieun; Ki, Moran; Cho, Yong Kyun; Lim, Seung Kwan; Lee, Jin Seo; Kwon, Ki Tae; Lee, Hyuck; Cheong, Hee Jin; Park, Dae Won; Ryu, Seong Yeol; Chung, Moon Hyun; Pai, Hyunjoo
- Issue Date
- 1월-2021
- Publisher
- MDPI
- Keywords
- urinary tract infection; pyelonephritis; E; coli; fluoroquinolone; treatment
- Citation
- ANTIBIOTICS-BASEL, v.10, no.1, pp.1 - 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTIBIOTICS-BASEL
- Volume
- 10
- Number
- 1
- Start Page
- 1
- End Page
- 6
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/50290
- DOI
- 10.3390/antibiotics10010037
- ISSN
- 2079-6382
- Abstract
- The purpose of this study was to determine whether the fluoroquinolone (FQ) minimum inhibitory concentration (MIC) for the causative agent Escherichia coli influences the clinical response of FQ treatment at 72 h in patients with community-acquired acute pyelonephritis (CA-APN). We prospectively collected the clinical data of women with CA-APN from 11 university hospitals from March 2010 to February 2012 as well as E. coli isolates from the urine or blood. In total, 78 patients included in this study received FQ during the initial 72 h, and the causative E. coli was detected. The clinical response at 72 h was significantly higher in patients with a levofloxacin MIC <= 16 mg/L than in those with an MIC > 16 mg/L (70.4% vs. 28.6%, p = 0.038). No difference was observed in clinical response at 72 h based on ciprofloxacin MIC. To summarize, FQ can be an effective treatment option for CA-APN when levofloxacin MIC against E. coli is <= 16 mg/L.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.