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Cited 3 time in webofscience Cited 3 time in scopus
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Prediction of 7-year's conversion from subjective cognitive decline to mild cognitive impairment

Authors
Yue, LingHu, DanZhang, HanWen, JunhaoWu, YeLi, WeiSun, LinLi, XiaWang, JinghuaLi, GuanjunWang, TaoShen, DinggangXiao, Shifu
Issue Date
1월-2021
Publisher
WILEY
Keywords
machine learning; MRI; prediction; subjective cognitive decline
Citation
HUMAN BRAIN MAPPING, v.42, no.1, pp.192 - 203
Indexed
SCIE
SCOPUS
Journal Title
HUMAN BRAIN MAPPING
Volume
42
Number
1
Start Page
192
End Page
203
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/50306
DOI
10.1002/hbm.25216
ISSN
1065-9471
Abstract
Subjective cognitive decline (SCD) is a high-risk yet less understood status before developing Alzheimer's disease (AD). This work included 76 SCD individuals with two (baseline and 7 years later) neuropsychological evaluations and a baseline T1-weighted structural MRI. A machine learning-based model was trained based on 198 baseline neuroimaging (morphometric) features and a battery of 25 clinical measurements to discriminate 24 progressive SCDs who converted to mild cognitive impairment (MCI) at follow-up from 52 stable SCDs. The SCD progression was satisfactorily predicted with the combined features. A history of stroke, a low education level, a low baseline MoCA score, a shrunk left amygdala, and enlarged white matter at the banks of the right superior temporal sulcus were found to favor the progression. This is to date the largest retrospective study of SCD-to-MCI conversion with the longest follow-up, suggesting predictable far-future cognitive decline for the risky populations with baseline measures only. These findings provide valuable knowledge to the future neuropathological studies of AD in its prodromal phase.
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