Clinical implication of tumour spread through air spaces in pathological stage I lung adenocarcinoma treated with lobectomy
DC Field | Value | Language |
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dc.contributor.author | Yi, Eunjue | - |
dc.contributor.author | Lee, Jeong Hyeon | - |
dc.contributor.author | Jung, Younggi | - |
dc.contributor.author | Chung, Jae Ho | - |
dc.contributor.author | Lee, Youngseok | - |
dc.contributor.author | Lee, Sungho | - |
dc.date.accessioned | 2021-08-30T05:04:45Z | - |
dc.date.available | 2021-08-30T05:04:45Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1569-9293 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50626 | - |
dc.description.abstract | OBJECTIVES: The aim of this study was to evaluate the clinical implication of tumour spread through air spaces (STAS) as a prognostic factor in pathological stage I lung adenocarcinoma treated with lobectomy and to identify related parameters. METHODS: Medical records of patients who underwent pulmonary lobectomy for stage I (American Joint Committee on Cancers eighth edition) lung adenocarcinomas between 2012 and February 2018 at our institutions were reviewed retrospectively. Patients with minimally invasive adenocarcinomas and tumours >3 cm in size were excluded. Included patients were classified into STAS (+) and STAS (-) groups. Clinical implications of STAS and recurrence in patients were investigated. RESULTS: A total of 109 patients was analysed: 41 (37.6%) in the STAS (+) and 68 (62.4%) in the STAS (-) group. STAS was associated with larger consolidation diameter on chest tomography (>= 1.5 cm; P = 0.006) or a higher invasive ratio (>= 85%; P = 0.012) and presence of a micropapillary pattern in multivariable analysis (P = 0.003) The recurrence-free survival curve showed statistical difference (P = 0.008) with 3-year survival rates of 73.0% (9 patients) and 96.8% (2 patients) in the STAS (+) and STAS (-) group, respectively. However, no statistical significance was observed in the lung cancer-related survival curve (P = 0.648). The presence of STAS was an independent risk factor for recurrence in multivariable analysis (hazard ratio = 5.9, P = 0.031). CONCLUSIONS: The presence of STAS could be an important risk factor for recurrence in patients with early-stage invasive lung adenocarcinoma treated with pulmonary lobectomy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | LIMITED RESECTION | - |
dc.subject | MICROPAPILLARY PATTERN | - |
dc.subject | PROGNOSTIC IMPACT | - |
dc.subject | CANCER | - |
dc.subject | RECURRENCE | - |
dc.subject | CLASSIFICATION | - |
dc.subject | INVASION | - |
dc.subject | ISLANDS | - |
dc.subject | SURGERY | - |
dc.subject | MARKER | - |
dc.title | Clinical implication of tumour spread through air spaces in pathological stage I lung adenocarcinoma treated with lobectomy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sungho | - |
dc.identifier.doi | 10.1093/icvts/ivaa227 | - |
dc.identifier.scopusid | 2-s2.0-85099172667 | - |
dc.identifier.wosid | 000608419000008 | - |
dc.identifier.bibliographicCitation | INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, v.32, no.1, pp.64 - 72 | - |
dc.relation.isPartOf | INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY | - |
dc.citation.title | INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 64 | - |
dc.citation.endPage | 72 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | LIMITED RESECTION | - |
dc.subject.keywordPlus | MICROPAPILLARY PATTERN | - |
dc.subject.keywordPlus | PROGNOSTIC IMPACT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | ISLANDS | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordAuthor | Invasive adenocarcinoma | - |
dc.subject.keywordAuthor | Lobectomy | - |
dc.subject.keywordAuthor | Prognosis | - |
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