Substrate specificity of bacterial endoribonuclease toxins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Yoontak | - |
dc.contributor.author | Lee, Eun-Jin | - |
dc.date.accessioned | 2021-08-30T05:18:09Z | - |
dc.date.available | 2021-08-30T05:18:09Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-12-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50747 | - |
dc.description.abstract | Bacterial endoribonuclease toxins belong to a protein family that inhibits bacterial growth by degrading mRNA or rRNA sequences. The toxin genes are organized in pairs with its cognate antitoxins in the chromosome and thus the activities of the toxins are antagonized by antitoxin proteins or RNAs during active translation. In response to a variety of cellular stresses, the endoribonuclease toxins appear to be released from antitoxin molecules via proteolytic cleavage of antitoxin proteins or preferential degradation of antitoxin RNAs and cleave a diverse range of mRNA or rRNA sequences in a sequence-specific or codon-specific manner, resulting in various biological phenomena such as antibiotic tolerance and persister cell formation. Given that substrate specificity of each endoribonuclease toxin is determined by its structure and the composition of active site residues, we summarize the biology, structure, and substrate specificity of the updated bacterial endoribonuclease toxins. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | MESSENGER-RNA CLEAVAGE | - |
dc.subject | ABORTIVE INFECTION MECHANISM | - |
dc.subject | KILLER GENE SYSTEM | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | STABLE MAINTENANCE | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | ANTITOXIN SYSTEM | - |
dc.subject | STRUCTURAL BASIS | - |
dc.subject | YOEB TOXIN | - |
dc.subject | CELL-DEATH | - |
dc.title | Substrate specificity of bacterial endoribonuclease toxins | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Eun-Jin | - |
dc.identifier.doi | 10.5483/BMBRep.2020.53.12.203 | - |
dc.identifier.scopusid | 2-s2.0-85099172169 | - |
dc.identifier.wosid | 000604903900001 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.53, no.12, pp.611 - 621 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 53 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 611 | - |
dc.citation.endPage | 621 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002664406 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | MESSENGER-RNA CLEAVAGE | - |
dc.subject.keywordPlus | ABORTIVE INFECTION MECHANISM | - |
dc.subject.keywordPlus | KILLER GENE SYSTEM | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | STABLE MAINTENANCE | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ANTITOXIN SYSTEM | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | YOEB TOXIN | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordAuthor | Endoribonuclease | - |
dc.subject.keywordAuthor | Persister cells | - |
dc.subject.keywordAuthor | Recognition sequence | - |
dc.subject.keywordAuthor | Ribosome | - |
dc.subject.keywordAuthor | Toxin-antitoxin system | - |
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