Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | Go, Yoon Young | - |
dc.contributor.author | Kim, Su Ra | - |
dc.contributor.author | Kim, Do Yeon | - |
dc.contributor.author | Chae, Sung-Won | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.date.accessioned | 2021-08-30T05:20:00Z | - |
dc.date.available | 2021-08-30T05:20:00Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-12-26 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/50766 | - |
dc.description.abstract | Cannabidiol (CBD) has anti-tumorigenic activity. However, the anti-cancer effect of CBD on head and neck squamous cell carcinoma (HNSCC) remains unclear. The cytotoxicity of CBD on HNSCC was analyzed using cell survival and colony-forming assays in vitro. RNA-seq was used for determining the mechanism underlying CBD-induced cell death. Xenograft mouse models were used to determine CBD's effects in vivo. CBD treatment significantly reduced migration/invasion and viability of HNSCC cells in a dose- and time-dependent manner. HNSCC mouse xenograft models revealed anti-tumor effects of CBD. Furthermore, combinational treatment with CBD enhanced the efficacy of chemotherapy drugs. Apoptosis and autophagy processes were involved in CBD-induced cytotoxicity of HNSCCs. RNA-seq identified decreased expression of genes associated with DNA repair, cell division, and cell proliferation, which were involved in CBD-mediated cytotoxicity toward HNSCCs. We identified CBD as a new potential anti-cancer compound for single or combination therapy of HNSCC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.subject | CANCER CELLS | - |
dc.subject | APOPTOSIS | - |
dc.subject | METASTASIS | - |
dc.subject | INHIBITION | - |
dc.subject | PROLIFERATION | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | EXPRESSION | - |
dc.subject | INVASION | - |
dc.subject | STRESS | - |
dc.subject | GROWTH | - |
dc.title | Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Go, Yoon Young | - |
dc.contributor.affiliatedAuthor | Song, Jae-Jun | - |
dc.identifier.doi | 10.1038/s41598-020-77674-y | - |
dc.identifier.scopusid | 2-s2.0-85096601003 | - |
dc.identifier.wosid | 000596327100005 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | GROWTH | - |
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