Detailed Information

Cited 2 time in webofscience Cited 4 time in scopus
Metadata Downloads

Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma

Full metadata record
DC Field Value Language
dc.contributor.authorGo, Yoon Young-
dc.contributor.authorKim, Su Ra-
dc.contributor.authorKim, Do Yeon-
dc.contributor.authorChae, Sung-Won-
dc.contributor.authorSong, Jae-Jun-
dc.date.accessioned2021-08-30T05:20:00Z-
dc.date.available2021-08-30T05:20:00Z-
dc.date.created2021-06-18-
dc.date.issued2020-12-26-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/50766-
dc.description.abstractCannabidiol (CBD) has anti-tumorigenic activity. However, the anti-cancer effect of CBD on head and neck squamous cell carcinoma (HNSCC) remains unclear. The cytotoxicity of CBD on HNSCC was analyzed using cell survival and colony-forming assays in vitro. RNA-seq was used for determining the mechanism underlying CBD-induced cell death. Xenograft mouse models were used to determine CBD's effects in vivo. CBD treatment significantly reduced migration/invasion and viability of HNSCC cells in a dose- and time-dependent manner. HNSCC mouse xenograft models revealed anti-tumor effects of CBD. Furthermore, combinational treatment with CBD enhanced the efficacy of chemotherapy drugs. Apoptosis and autophagy processes were involved in CBD-induced cytotoxicity of HNSCCs. RNA-seq identified decreased expression of genes associated with DNA repair, cell division, and cell proliferation, which were involved in CBD-mediated cytotoxicity toward HNSCCs. We identified CBD as a new potential anti-cancer compound for single or combination therapy of HNSCC.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherNATURE RESEARCH-
dc.subjectCANCER CELLS-
dc.subjectAPOPTOSIS-
dc.subjectMETASTASIS-
dc.subjectINHIBITION-
dc.subjectPROLIFERATION-
dc.subjectANGIOGENESIS-
dc.subjectEXPRESSION-
dc.subjectINVASION-
dc.subjectSTRESS-
dc.subjectGROWTH-
dc.titleCannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma-
dc.typeArticle-
dc.contributor.affiliatedAuthorGo, Yoon Young-
dc.contributor.affiliatedAuthorSong, Jae-Jun-
dc.identifier.doi10.1038/s41598-020-77674-y-
dc.identifier.scopusid2-s2.0-85096601003-
dc.identifier.wosid000596327100005-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.10, no.1-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume10-
dc.citation.number1-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusCANCER CELLS-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusMETASTASIS-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusINVASION-
dc.subject.keywordPlusSTRESS-
dc.subject.keywordPlusGROWTH-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Song, Jae Jun photo

Song, Jae Jun
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE