Angiotensin inhibition and cellular senescence in the developing rat kidney
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Kee Hwan | - |
dc.contributor.author | Yim, Hyung Eun | - |
dc.contributor.author | Bae, Eun Soo | - |
dc.date.accessioned | 2021-08-30T06:37:56Z | - |
dc.date.available | 2021-08-30T06:37:56Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 0014-4800 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/51234 | - |
dc.description.abstract | Cellular senescence is important for the maintenance of tissue homeostasis during normal development. In this study, we aimed to investigate the effect of renin angiotensin system (RAS) blockade on renal cell senescence in the developing rat kidney. Newborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle for seven days after birth. We investigated the intrarenal expressions of cell cycle regulators p21 and p16 with immunoblots and immunohistochemistry at postnatal day 8. For the determination of renal cellular senescence, immunostaining for senescence-associated beta-galactosidase (SA-beta-gal) and telomerase reverse transcriptase (TERT) was also performed. Enalapril treatment showed significant alterations in cellular senescence in neonatal rat kidneys. In the enalapril-treated group, intrarenal p16 and p21 protein expressions decreased compared to controls. The expressions of both p21 and p16 were reduced throughout the renal cortex and medulla of enalapril-treated rats. The immunoreactivity of TERT in enalapril-treated kidneys was also weaker than that in control kidneys. Control kidneys revealed a clear positive SA-beta-gal signal in the cortical tubules; however, SA-beta-gal activity was noticeably lower in the enalapril-treated kidneys than in control kidneys. Interruption of the RAS during postnatal nephrogenesis may disrupt physiologic renal cellular senescence in the developing rat kidney. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Angiotensin inhibition and cellular senescence in the developing rat kidney | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Kee Hwan | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Eun | - |
dc.identifier.doi | 10.1016/j.yexmp.2020.104551 | - |
dc.identifier.scopusid | 2-s2.0-85091895984 | - |
dc.identifier.wosid | 000596759500001 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR PATHOLOGY, v.117 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR PATHOLOGY | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR PATHOLOGY | - |
dc.citation.volume | 117 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Cellular senescence | - |
dc.subject.keywordAuthor | Fetal development | - |
dc.subject.keywordAuthor | Kidney | - |
dc.subject.keywordAuthor | Renin-angiotensin system | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.