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Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder

Authors
Kang, WooyoungShin, Jeong-HyeonHan, Kyu-ManKim, AramKang, YoubinKang, JuneTae, Woo-SukPaik, Jong-WooLee, Hae-WooSeong, Joon-KyungHam, Byung-Joo
Issue Date
12월-2020
Publisher
WILEY
Keywords
basal ganglia; LCSPT circuits; local shape volume; major depressive disorder; stress; suicidality; thalamus
Citation
HUMAN BRAIN MAPPING, v.41, no.17, pp.4925 - 4934
Indexed
SCIE
SCOPUS
Journal Title
HUMAN BRAIN MAPPING
Volume
41
Number
17
Start Page
4925
End Page
4934
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/51249
DOI
10.1002/hbm.25168
ISSN
1065-9471
Abstract
Suicide is among the most important global health concerns; accordingly, an increasing number of studies have shown the risks for suicide attempt(s) in terms of brain morphometric features and their clinical correlates. However, brain studies addressing suicidal vulnerability have been more focused on demonstrating impairments in cortical structures than in the subcortical structures. Using local shape volumes (LSV) analysis, we investigated subcortical structures with their clinical correlates in depressed patients who attempted suicide. Then we compared them with depressed patients without a suicidal history and age- and sex-matched healthy controls (HCs; i.e., 47 suicide attempters with depression, 47 non-suicide attempters with depression, and 109 HCs). Significant volumetric differences were found between suicidal and nonsuicidal depressed patients in several vertices: 16 in the left amygdala; 201 in the left hippocampus; 1,057 in the left putamen; and 140 in the left pallidum; 1 in the right pallidum; and 6 in the bilateral thalamus. These findings indicated subcortical alterations in LSV in components of the limbic-cortical-striatal-pallidal-thalamic circuits. Moreover, our results demonstrated that the basal ganglia was correlated with perceived stress levels, and the thalamus was correlated with suicidal ideation. We suggest that suicidality in major depressive disorder may involve subcortical volume alterations.
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