Comparison of High-Dose Rosuvastatin Versus Low-Dose Rosuvastatin Plus Ezetimibe on Carotid Atherosclerotic Plaque Inflammation in Patients with Acute Coronary Syndrome
- Authors
- Oh, Minyoung; Kim, Hyunji; Shin, Eon Woo; Sung, Changhwan; Kim, Do-Hoon; Moon, Dae Hyuk; Kim, Nayoung; Eo, Jae Seon; Kim, Jin Won; Lee, Cheol Whan
- Issue Date
- 12월-2020
- Publisher
- SPRINGER
- Keywords
- Ezetimibe; Plaque inflammation; Statin; Positron emission tomography
- Citation
- JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, v.13, no.6, pp.900 - 907
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
- Volume
- 13
- Number
- 6
- Start Page
- 900
- End Page
- 907
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/51353
- DOI
- 10.1007/s12265-020-10009-4
- ISSN
- 1937-5387
- Abstract
- We compared the effects of ezetimibe/rosuvastatin 10/5 mg versus rosuvastatin 20 mg on carotid atherosclerotic plaque inflammation measured by (18)FDG PET/CT. Fifty patients with acute coronary syndrome (ACS) were randomly assigned to the ezetimibe/rosuvastatin 10/5 mg and rosuvastatin 20 mg groups. The primary outcome was the percent change in the target-to-background ratio (TBR) of the index vessel in the most diseased segment (MDS), as assessed by (18)FDG PET/CT at baseline and at 6 months. Forty-eight patients completed follow-up PET/CT. MDS TBR was - 6.2 +/- 13.9% for patients in the ezetimibe/rosuvastatin group and - 10.8 +/- 17.7% for those in the rosuvastatin group (difference, 4.6 percentage points; upper limitation of one-sided confidence interval = 13.8; p = 0.60 for noninferiority). In conclusion, combination therapy with ezetimibe 10 mg and rosuvastatin 5 mg compared with rosuvastatin 20 mg did not meet the criterion for non-inferiority for primary outcome, and the present study was not conclusive on whether the former was non-inferior to the latter.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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