Synthesis and Cytotoxicity Studies of Bioactive Benzofurans from Lavandula agustifolia and Modified Synthesis of Ailanthoidol, Homoegonol, and Egonol
DC Field | Value | Language |
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dc.contributor.author | Sivaraman, Aneesh | - |
dc.contributor.author | Kim, Jin Sook | - |
dc.contributor.author | Harmalkar, Dipesh S. | - |
dc.contributor.author | Min, Kyoung Ho | - |
dc.contributor.author | Park, Joong-Won | - |
dc.contributor.author | Choi, Yongseok | - |
dc.contributor.author | Kim, Kyungtae | - |
dc.contributor.author | Lee, Kyeong | - |
dc.date.accessioned | 2021-08-30T07:54:20Z | - |
dc.date.available | 2021-08-30T07:54:20Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-11-25 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/51449 | - |
dc.description.abstract | 2-Aryl/alkylbenzofurans, which constitute an important subclass of naturally occurring lignans and neolignans, have attracted extensive synthetic efforts due to their useful biological activities and significant pharmacological potential. Herein, we report a general and efficient approach to divergent 2-arylbenzofurans through a one-pot synthesis of versatile 2-bromobenzofurans as key intermediates. Using this approach, the first total synthesis of a series of trisubstituted and tetrasubstituted benzofurans bearing the hydroxyethyl unit, including the natural compounds isolated from Lavandula agustifolia (1-3) and their non-natural derivatives (4-8), was accomplished. We also report a modified synthesis of ailanthoidol, homoegonol, and egonol that enables the divergent synthesis of their derivatives for future exploration. Among these, the representative phenolic natural compound 2 and its derivatives 7 and 5 induced apoptotic cell death related poly(ADP-ribose) polymerase (PARP) cleavage in MCF74, A549, PC3, HepG2, and Hep3B cancer cell lines. Additionally, the tumor suppressor protein p53 was also induced in p53 wild type cancer cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Synthesis and Cytotoxicity Studies of Bioactive Benzofurans from Lavandula agustifolia and Modified Synthesis of Ailanthoidol, Homoegonol, and Egonol | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
dc.identifier.doi | 10.1021/acs.jnatprod.0c00697 | - |
dc.identifier.scopusid | 2-s2.0-85096210635 | - |
dc.identifier.wosid | 000595546200017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.83, no.11, pp.3354 - 3362 | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 83 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3354 | - |
dc.citation.endPage | 3362 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
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