Characterization of alpha-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seul Ki | - |
dc.contributor.author | Ryu, Se Hwan | - |
dc.contributor.author | Turk, Ayman | - |
dc.contributor.author | Yeon, Sang Won | - |
dc.contributor.author | Jo, Yang Hee | - |
dc.contributor.author | Han, Yoo Kyong | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.date.accessioned | 2021-08-30T08:41:45Z | - |
dc.date.available | 2021-08-30T08:41:45Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-11-15 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/51506 | - |
dc.description.abstract | Ethnopharmacological relevance: Hericium erinaceus, commonly called lion's mane mushroom, is an edible and medicinal mushroom that has been traditionally used for the treatment of metabolic disorders, gastrointestinal diseases and memory impairment. In this study, potential anti-hyperglycemic constituents were identified to support the traditional usage of H. erinaceus. Materials and methods: The components of H. erinaceus were purified using various column chromatography techniques. The structure of the separated compounds was determined based on spectroscopic data analysis, i.e., 1D and 2D NMR analysis. The anti-hyperglycemic activity of the isolated compounds was evaluated by measuring the inhibitory effects on alpha-glucosidase activity. Molecular docking analysis was also conducted for elucidation of alpha-glucosidase inhibitory activity of isolated compounds. Results: Ten compounds including four new compounds, erinacenols A-D (1-4), were isolated from the fruiting bodies of H. erinaceus. Investigation of the anti-hyperglycemic effect of isolated compounds demonstrated that erinacenol D (4), 4-[3 ',7 '-dimethyl-2 ',6 '-octadienyl]-2-formyl-3-hydroxy-5-methyoxybenzylalcohol (6), hericene A (7), hericene D (8) and hericenone D (9) strongly inhibited alpha-glucosidase activity with IC50 values of <20 mu M. The structure activity relationship suggested the importance of long side chain for alpha-glucosidase inhibitory activity. Further analysis by molecular docking demonstrated the interaction of alpha-glucosidase and isolated compounds, which supported the inhibitory activity of alpha-glucosidase. Conclusion: Our present study demonstrated the beneficial effect of H. erinaceus by characterization of alpha-glucosidase inhibitory compounds, including four new compounds. This approach can be valuable support for the traditional use of H. erinaceus for the treatment of diabetes and metabolic diseases, which needs to be clarified by further in-vivo study. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | TYPE-2 DIABETES-MELLITUS | - |
dc.subject | AROMATIC-COMPOUNDS | - |
dc.subject | YAMABUSHITAKE | - |
dc.subject | MICE | - |
dc.title | Characterization of alpha-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.identifier.doi | 10.1016/j.jep.2020.113197 | - |
dc.identifier.scopusid | 2-s2.0-85088859032 | - |
dc.identifier.wosid | 000569288800002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.262 | - |
dc.relation.isPartOf | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 262 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | AROMATIC-COMPOUNDS | - |
dc.subject.keywordPlus | YAMABUSHITAKE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | Hericium erinaceus | - |
dc.subject.keywordAuthor | Erinacenols A-D | - |
dc.subject.keywordAuthor | alpha-Glucosidase | - |
dc.subject.keywordAuthor | Molecular docking analysis | - |
dc.subject.keywordAuthor | Diabetes | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.