Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seung Min | - |
dc.contributor.author | Park, Jongmin | - |
dc.contributor.author | Kim, Myun Soo | - |
dc.contributor.author | Song, Heebum | - |
dc.contributor.author | Jo, Ala | - |
dc.contributor.author | Park, Hankum | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Choi, Sang Ho | - |
dc.contributor.author | Park, Seung Bum | - |
dc.date.accessioned | 2021-08-30T09:03:50Z | - |
dc.date.available | 2021-08-30T09:03:50Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-11-13 | - |
dc.identifier.issn | 2373-8227 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/51810 | - |
dc.description.abstract | An antivirulence agent against Vibrio vulnificus named quoromycin (QM) was discovered by a phenotype-based elastase inhibitor screening. Using the fluorescence difference in two-dimensional gel electrophoresis (FITGE) approach, SmcR, a quorum-sensing master regulator and homologue of LuxR, was identified as the target protein of QM. We confirmed that the direct binding of QM to SmcR inhibits the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviates the virulence of V. vulnificus in vitro and in vivo. QM can be regarded as a novel antivirulence agent for the treatment of V. vulnificus infection. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1021/acsinfecdis.0c00587 | - |
dc.identifier.scopusid | 2-s2.0-85096071550 | - |
dc.identifier.wosid | 000592747600026 | - |
dc.identifier.bibliographicCitation | ACS INFECTIOUS DISEASES, v.6, no.11, pp.3076 - 3082 | - |
dc.relation.isPartOf | ACS INFECTIOUS DISEASES | - |
dc.citation.title | ACS INFECTIOUS DISEASES | - |
dc.citation.volume | 6 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3076 | - |
dc.citation.endPage | 3082 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.subject.keywordAuthor | antivirulence agent | - |
dc.subject.keywordAuthor | Vibrio vulnificus | - |
dc.subject.keywordAuthor | SmcR | - |
dc.subject.keywordAuthor | target identification | - |
dc.subject.keywordAuthor | quorum sensing | - |
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