Impact of DBPs on the fate of zebrafish; Behavioral and lipid profile changes

Abstract

In recent years, the generation of disinfectant by-products (DBPs) in drinking water system has been highlighted for their potential negative impact on humans. A commonly used disinfectant, chlorine, produces a by-product which is highly hazardous and a known carcinogen. This study investigate the toxic effects of DBPs from several organic matter as a function of contact time with chlorine-based disinfectants were investigated using zebrafish. The results indicated that the generation of DBPs was dependent on the composition of dissolved organic matter (DOM) in water. Suwannee river natural organic matter and experimental site water sample (complex DOM) were almost 2.5 times higher than that of a single dissolved organic matter, such as microcystin-LR (MCLR) at 120 min. The behavior of zebrafish was significantly affected by complex composition DOM. In vivo biomarker analysis result from lipid profile analysis, reaction in vivo showed different depending on the composition of the DOM. Through this study, the effect of DBPs were observed via lipid metabolic and movement changes in aquatic organisms can be considered as a new biomarker for the drinking water risk assessment.