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Cited 1 time in webofscience Cited 2 time in scopus
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Characteristics of Exposure to Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) among Humidifier Disinfectant-Associated Lung Injury (HDLI) Patients in South Korea

Authors
Park, Dong-UkPark, Seon-KyungKim, JiwonPark, JihoonRyu, Seung-HunPark, Ju-HyunLee, So-YeonOh, Han BinKim, SungkyoonZoh, Kyung EhiPark, SoyoungKwon, Jung-Hwan
Issue Date
11월-2020
Publisher
MDPI
Keywords
humidifier disinfectant-associated lung injury (HDLI); humidifier disinfectant (HD); chloromethylisothiazolinone (CMIT); methylisothiazolinone (MIT); inhalation exposure; patient
Citation
MOLECULES, v.25, no.22
Indexed
SCIE
SCOPUS
Journal Title
MOLECULES
Volume
25
Number
22
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/51887
DOI
10.3390/molecules25225284
ISSN
1420-3049
Abstract
This study aimed to quantify both chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) dissolved in different product brands and to characterize the exposure to these chemicals among humidifier disinfectant-associated lung injury (HDLI) patients. Both CMIT and MIT dissolved in different humidifier disinfectant (HD) products were quantified using gas chromatography-mass spectrometry. The inhalation level of CMIT and MIT was estimated based on HD-associated factors as reported by HDLI patients. A total of eleven HD products marketed until the end of 2011 were found to contain CMIT and/or MIT. The level of combined CMIT and/or MIT dissolved in these HD products ranged from 12 to 353 ppm. The level varied among HD products and the year of manufacture. The average inhalation levels were estimated to be 7.5, 4.1, and 3.2 mu g/m(3) for the definite, probable, and possible groups, respectively. If probable and possible groups were collapsed together, the inhalation level of the collapsed group was significantly different from that of the definite group (p < 0.001). All HDLI patients responded as having used HD not only while sleeping, but also as having a humidifier treated with HD within close proximity every day in insufficiently ventilated spaces. These HD use characteristics of patients may be directly/indirectly linked to the HDLI development.
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Kwon, Jung Hwan
생명과학대학 (환경생태공학부)
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