Association of early-onset diabetes, prediabetes and early glycaemic recovery with the risk of all-cause and cardiovascular mortality
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Min | - |
dc.contributor.author | Lee, Gyeongsil | - |
dc.contributor.author | Choi, Seulggie | - |
dc.contributor.author | Kim, Kyuwoong | - |
dc.contributor.author | Jeong, Su-Min | - |
dc.contributor.author | Son, Joung Sik | - |
dc.contributor.author | Yun, Jae-Moon | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.contributor.author | Hwang, Seung-sik | - |
dc.contributor.author | Park, Seong Yong | - |
dc.contributor.author | Kim, Yeon-Yong | - |
dc.contributor.author | Park, Sang Min | - |
dc.date.accessioned | 2021-08-30T09:50:24Z | - |
dc.date.available | 2021-08-30T09:50:24Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 0012-186X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52064 | - |
dc.description.abstract | Aims/hypothesis The increasing incidence of diabetes among young adults is a disease burden; however, the effects of early-onset diabetes, prediabetes and glycaemic recovery on CVD or mortality remain unclear. We aimed to investigate the association of these factors with 10 year all-cause mortality, CVD mortality and CVD incidence in Korean young adults. Methods This large and longitudinal cohort study included data from the Korean National Health Insurance Service-National Health Information Database; 2,502,375 young adults aged 20-39 years without diabetes mellitus and CVD at baseline were included. Glycaemic status was measured twice, first in 2002-2003 and second in 2004-2005. Changes in fasting glucose levels were evaluated according to fasting glucose status: normal fasting glucose (NFG; <5.5 mmol/l), impaired fasting glucose (IFG; 5.5-6.9 mmol/l), and diabetic fasting glucose (DFG; >= 7.0 mmol/l). Primary outcomes were all-cause and CVD mortality risk. The secondary outcome was incidence of CVD, including acute myocardial infarction and stroke. All outcomes arose from the 10 year follow-up period 1 Jan 2006 to 31 December 2015. Results Individuals with NFG at baseline, who were subsequently newly diagnosed with diabetes and prediabetes (IFG), had increased all-cause mortality (HR [95% CI] 1.60 [1.44, 1.78] and 1.13 [1.09, 1.18], respectively) and CVD incidence (1.13 [1.05, 1.23] and 1.04 [1.01, 1.07], respectively). In those with DFG at baseline, early recovery to NFG and IFG was associated with decreased all-cause mortality (0.57 [0.46, 0.70] and 0.65 [0.53, 0.81], respectively) and CVD incidence (0.70 [0.60, 0.81] and 0.78 [0.66, 0.91], respectively). Among patients with IFG at baseline, early recovery to NFG was associated with decreased CVD mortality (0.74 [0.59, 0.93]). Conclusions/interpretation Early-onset diabetes or prediabetes increased CVD risks and all-cause mortality after the 10 year follow-up. Furthermore, recovery of hyperglycaemia could reduce the subsequent 10 year risk for CVD incidence and all-cause mortality. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | IMPAIRED FASTING GLUCOSE | - |
dc.subject | YOUNG-ADULTS | - |
dc.subject | TYPE-2 | - |
dc.subject | COMPLICATIONS | - |
dc.subject | DISEASE | - |
dc.subject | ADOLESCENTS | - |
dc.subject | MELLITUS | - |
dc.subject | UKPDS | - |
dc.title | Association of early-onset diabetes, prediabetes and early glycaemic recovery with the risk of all-cause and cardiovascular mortality | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.identifier.doi | 10.1007/s00125-020-05252-y | - |
dc.identifier.scopusid | 2-s2.0-85089678604 | - |
dc.identifier.wosid | 000561230700001 | - |
dc.identifier.bibliographicCitation | DIABETOLOGIA, v.63, no.11, pp.2305 - 2314 | - |
dc.relation.isPartOf | DIABETOLOGIA | - |
dc.citation.title | DIABETOLOGIA | - |
dc.citation.volume | 63 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2305 | - |
dc.citation.endPage | 2314 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | IMPAIRED FASTING GLUCOSE | - |
dc.subject.keywordPlus | YOUNG-ADULTS | - |
dc.subject.keywordPlus | TYPE-2 | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ADOLESCENTS | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | UKPDS | - |
dc.subject.keywordAuthor | All-cause mortality | - |
dc.subject.keywordAuthor | Cardiovascular disease | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Glycaemic recovery | - |
dc.subject.keywordAuthor | Prediabetes | - |
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