LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1
DC Field | Value | Language |
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dc.contributor.author | Yoo, Jung-Yeon | - |
dc.contributor.author | Cha, Dae Ryong | - |
dc.contributor.author | Kim, Borim | - |
dc.contributor.author | An, Eun Jung | - |
dc.contributor.author | Lee, Sae Rom | - |
dc.contributor.author | Cha, Jin Joo | - |
dc.contributor.author | Kang, Young Sun | - |
dc.contributor.author | Ghee, Jung Yeon | - |
dc.contributor.author | Han, Jee Young | - |
dc.contributor.author | Bae, Yun Soo | - |
dc.date.accessioned | 2021-08-30T10:23:07Z | - |
dc.date.available | 2021-08-30T10:23:07Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-10-20 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52425 | - |
dc.description.abstract | Cytosolic proteins are required for regulation of NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (Nox) isozymes. Here we show that Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1), as a Nox4 cytosolic regulator, mediates lipopolysaccharide (LPS)-induced H2O2 generation, leading to acute kidney injury. The SH3YL1, Ysc84p/Lsb4p, Lsb3p, and plant FYVE proteins (SYLF) region and SH3 domain of SH3YL1 contribute to formation of a complex with Nox4-p22(p)(hox) Interaction of p22(p)(hox) with SH3YL1 is triggered by LPS, and the complex induces H2O2 generation and pro-inflammatory cytokine expression in mouse tubular epithelial cells. After LPS injection, SH3YL1 knockout mice show lower levels of acute kidney injury biomarkers, decreased secretion of pro-inflammatory cytokines, decreased infiltration of macrophages, and reduced tubular damage compared with wild-type (WT) mice. The results strongly suggest that SH3YL1 is involved in renal failure in LPS-induced acute kidney injury (AKI) mice. We demonstrate that formation of a ternary complex of p22(p)(hox)-SH3YL1-Nox4, leading to H2O2 generation, induces severe renal failure in the LPS-induced AKI model. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | OXYGEN SPECIES GENERATION | - |
dc.subject | CRITICALLY-ILL PATIENTS | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | NADPH OXIDASE 1 | - |
dc.subject | REACTIVE OXYGEN | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | NOX FAMILY | - |
dc.subject | SEPSIS | - |
dc.subject | ACTIVATION | - |
dc.subject | MECHANISMS | - |
dc.title | LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cha, Dae Ryong | - |
dc.contributor.affiliatedAuthor | Cha, Jin Joo | - |
dc.identifier.doi | 10.1016/j.celrep.2020.108245 | - |
dc.identifier.scopusid | 2-s2.0-85093690384 | - |
dc.identifier.wosid | 000582719300001 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.33, no.3 | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | OXYGEN SPECIES GENERATION | - |
dc.subject.keywordPlus | CRITICALLY-ILL PATIENTS | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | NADPH OXIDASE 1 | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NOX FAMILY | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | AKI | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | H2O2, LPS | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | Nox4 | - |
dc.subject.keywordAuthor | sepsis | - |
dc.subject.keywordAuthor | SH3YL1 | - |
dc.subject.keywordAuthor | TLR4 | - |
dc.subject.keywordAuthor | tubular damage | - |
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