Statin Effects in Atrial Fibrillation-Related Stroke: A Systematic Review and Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Eun, Mi-Yeon | - |
dc.contributor.author | Jung, Jin-Man | - |
dc.contributor.author | Choi, Kang-Ho | - |
dc.contributor.author | Seo, Woo-Keun | - |
dc.date.accessioned | 2021-08-30T11:14:02Z | - |
dc.date.available | 2021-08-30T11:14:02Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-10-09 | - |
dc.identifier.issn | 1664-2295 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52476 | - |
dc.description.abstract | Background:Statins lower the risk of recurrent stroke and mortality and improve outcomes in patients with ischemic stroke. However, the effects of statins on atrial fibrillation (AF)-related stroke are not well-established. Our study aims to investigate the effects of statin therapy on the clinical outcomes in patients with AF-related stroke. Methods:Electronic databases (MEDLINE, Embase, and Scopus) were searched for previous studies on the effects of pre- and post-stroke statins on the clinical outcomes in AF-related stroke patients. The primary outcome was all-cause mortality. Secondary outcomes included recurrent ischemic stroke, acute coronary events, major adverse cardiovascular events (MACE), and short-term functional outcomes. We extracted hazard ratios (HRs) or odds ratios (ORs) with 95% confidence interval (CI) from each study and pooled them through a meta-analysis. Results:A total of eight studies (five on post-stroke statins and three on pre-stroke statins) with 12,216 patients were included in the analysis. Post-stroke statin therapy reduced the risk of all-cause mortality (HR, 0.63; 95% CI, 0.55-0.74). This beneficial effect was sustained regardless of statin intensity. However, no significant associations were observed between statin therapy and a reduction in the risk of recurrent ischemic stroke, acute coronary events, or MACE. Pre-stroke statin use was associated with a lower risk of poor short-term functional outcomes (OR, 0.63; 95% CI, 0.47-0.85). Conclusions:Statin therapy for AF-related stroke may reduce all-cause mortality and improve functional outcomes. Randomized controlled studies are warranted to confirm the effects of statins on the outcomes of AF-related stroke. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | CLINICAL-OUTCOMES | - |
dc.subject | RISK-FACTORS | - |
dc.subject | THERAPY | - |
dc.subject | ASSOCIATION | - |
dc.subject | MORTALITY | - |
dc.subject | SURVIVAL | - |
dc.subject | INTENSITY | - |
dc.subject | PROGNOSIS | - |
dc.title | Statin Effects in Atrial Fibrillation-Related Stroke: A Systematic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Jin-Man | - |
dc.identifier.doi | 10.3389/fneur.2020.589684 | - |
dc.identifier.scopusid | 2-s2.0-85094612403 | - |
dc.identifier.wosid | 000581044500001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROLOGY, v.11 | - |
dc.relation.isPartOf | FRONTIERS IN NEUROLOGY | - |
dc.citation.title | FRONTIERS IN NEUROLOGY | - |
dc.citation.volume | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | INTENSITY | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordAuthor | atrial fibrillation | - |
dc.subject.keywordAuthor | statins | - |
dc.subject.keywordAuthor | stroke | - |
dc.subject.keywordAuthor | mortality | - |
dc.subject.keywordAuthor | functional outcome | - |
dc.subject.keywordAuthor | systematic review | - |
dc.subject.keywordAuthor | meta-analysis | - |
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