Comparison of optical coherence tomography-guided versus intravascular ultrasound-guided percutaneous coronary intervention: Rationale and design of a randomized, controlled OCTIVUS trial
DC Field | Value | Language |
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dc.contributor.author | Kang, Yoon | - |
dc.contributor.author | Ahn, Jung-Min | - |
dc.contributor.author | Park, Hanbit | - |
dc.contributor.author | Lee, Pil Hyung | - |
dc.contributor.author | Kang, Soo-Jin | - |
dc.contributor.author | Lee, Seung-Whan | - |
dc.contributor.author | Kim, Young-Hak | - |
dc.contributor.author | Park, Seong-Wook | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Cho, Yun-Kyeong | - |
dc.contributor.author | Lee, Cheol Hyun | - |
dc.contributor.author | Hong, Soon Jun | - |
dc.contributor.author | Hong, Young Joon | - |
dc.contributor.author | Yoon, Young Won | - |
dc.contributor.author | Kim, Soo-Joong | - |
dc.contributor.author | Bae, Jang-Ho | - |
dc.contributor.author | Oh, Jun-Hyok | - |
dc.contributor.author | Park, Duk-Woo | - |
dc.contributor.author | Park, Seung-Jung | - |
dc.date.accessioned | 2021-08-30T12:24:22Z | - |
dc.date.available | 2021-08-30T12:24:22Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0002-8703 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52554 | - |
dc.description.abstract | Background The clinical value of intracoronary imaging for percutaneous coronary intervention (PCI) guidance is well acknowledged. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are the most commonly used intravascular imaging to guide and optimize PCI in day-to-day practice. However, the comparative effectiveness of IVUSguided versus OCT-guided PCI with respect to clinical end points remains unknown. Methods and design The OCTIVUS study is a prospective, multicenter, open-label, parallel-cm, randomized trial comparing the effectiveness of 2 imaging-guided strategies in patients with stable angina or acute coronary syndromes undergoing PCI in Korea. A total of 2,000 patients are randomly assigned in a 1:1 ratio to either an OCT-guided PCI strategy or an IVUS-guided PCI strategy. The trial uses a pragmatic comparative effectiveness design with inclusion criteria designed to capture a broad range of real-world patients with diverse clinical and anatomical features. PCI optimization criteria are predefined using a common algorithm for online OCT or IVUS. The primary end point, which was tested for both noninferiority (margin, 3.1 percentage points for the risk difference) and superiority, is target-vessel failure (cardiac death, target-vessel myocardial infarction, or ischemia-driven target-vessel revascularization) at 1 year. Results Up to the end of July 2020, approximately 1,200 "real-world" PCI patients have been randomly enrolled over 2 years. Enrollment is expected to be completed around the midterm of 2021, and primary results will be available by late 2022 or early 2023. Conclusion This large-scale, multicenter, pragmatic-design clinical trial will provide valuable clinical evidence on the relative efficacy and safety of OCT-guided versus IVUS-guided PCI strategies in a broad population of patients undergoing PCI in the daily clinical practice. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.subject | ELUTING STENT IMPLANTATION | - |
dc.subject | EXPERT CONSENSUS DOCUMENT | - |
dc.subject | CLINICAL-PRACTICE | - |
dc.subject | AMERICAN-COLLEGE | - |
dc.subject | TASK-FORCE | - |
dc.subject | END-POINTS | - |
dc.subject | ANGIOGRAPHY | - |
dc.subject | METAANALYSIS | - |
dc.subject | DEFINITIONS | - |
dc.subject | STANDARDS | - |
dc.title | Comparison of optical coherence tomography-guided versus intravascular ultrasound-guided percutaneous coronary intervention: Rationale and design of a randomized, controlled OCTIVUS trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Soon Jun | - |
dc.identifier.doi | 10.1016/j.ahj.2020.08.003 | - |
dc.identifier.scopusid | 2-s2.0-85089893689 | - |
dc.identifier.wosid | 000572689300011 | - |
dc.identifier.bibliographicCitation | AMERICAN HEART JOURNAL, v.228, pp.72 - 80 | - |
dc.relation.isPartOf | AMERICAN HEART JOURNAL | - |
dc.citation.title | AMERICAN HEART JOURNAL | - |
dc.citation.volume | 228 | - |
dc.citation.startPage | 72 | - |
dc.citation.endPage | 80 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | ELUTING STENT IMPLANTATION | - |
dc.subject.keywordPlus | EXPERT CONSENSUS DOCUMENT | - |
dc.subject.keywordPlus | CLINICAL-PRACTICE | - |
dc.subject.keywordPlus | AMERICAN-COLLEGE | - |
dc.subject.keywordPlus | TASK-FORCE | - |
dc.subject.keywordPlus | END-POINTS | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | DEFINITIONS | - |
dc.subject.keywordPlus | STANDARDS | - |
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