Diagnostic Performance of the Prostate Cancer Antigen 3 Test in Prostate Cancer: Systematic Review and Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Donghyun | - |
dc.contributor.author | Shim, Sung Ryul | - |
dc.contributor.author | Ahn, Sun Tae | - |
dc.contributor.author | Oh, Mi Mi | - |
dc.contributor.author | Moon, Du Geon | - |
dc.contributor.author | Park, Hong Seok | - |
dc.contributor.author | Cheon, Jun | - |
dc.contributor.author | Kim, Jong Wook | - |
dc.date.accessioned | 2021-08-30T12:51:20Z | - |
dc.date.available | 2021-08-30T12:51:20Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1558-7673 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52571 | - |
dc.description.abstract | The purpose of this study was to assess the diagnostic accuracy of prostate cancer antigen 3 (PCA3) test for the diagnosis of prostate cancer through a systematic review and meta-analysis of 54 studies. Urinary PCA3 with a cutoff score of 35 had 71% pooled sensitivity and 68% pooled specificity. Urinary PCA3 is a noninvasive biomarker that can be used to aid in the diagnosis of prostate cancer. Purpose: To explore the diagnostic accuracy of prostate cancer antigen 3 (PCA3) test for the diagnosis of prostate cancer in this systematic review and meta-analysis. Patients and Methods: A systematic literature search of Medline, Embase, and Cochrane Library databases up to October 2019 was performed. The sensitivity, specificity, and diagnostic odds ratio with 95% confidence intervals (CIs) were calculated. The summary receiver operator characteristic graph came from individual studies. We also conducted metaregression analysis to identify the moderated factors. Results: Across 54 studies (17,575 patients), the pooled sensitivity, specificity, and diagnostic odds ratio of PCA3 were 0.71 (95% CI, 0.67-0.74), 0.68 (95% CI, 0.63-0.74), and 5.28 (95% CI, 4.28-6.51), respectively. The area under the summary receiver operator characteristic curve was 0.75 (95% CI, 0.71-0.79). Conclusion: Pooled data indicated that the PCA3 test had moderate sensitivity and specificity in the diagnosis of prostate cancer. PCA3 could be used as a noninvasive method for the diagnosis of prostate cancer. (C) 2020 The Author(s). Published by Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CIG MEDIA GROUP, LP | - |
dc.subject | MOLECULAR URINE ASSAY | - |
dc.subject | DIGITAL RECTAL EXAMINATION | - |
dc.subject | HEALTH INDEX | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | CLINICAL UTILITY | - |
dc.subject | REPEAT BIOPSY | - |
dc.subject | TUMOR VOLUME | - |
dc.subject | JAPANESE MEN | - |
dc.subject | PCA3 SCORE | - |
dc.subject | GENE | - |
dc.title | Diagnostic Performance of the Prostate Cancer Antigen 3 Test in Prostate Cancer: Systematic Review and Meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Moon, Du Geon | - |
dc.contributor.affiliatedAuthor | Kim, Jong Wook | - |
dc.identifier.doi | 10.1016/j.clgc.2020.03.005 | - |
dc.identifier.scopusid | 2-s2.0-85082936706 | - |
dc.identifier.wosid | 000582396100024 | - |
dc.identifier.bibliographicCitation | CLINICAL GENITOURINARY CANCER, v.18, no.5, pp.402 - + | - |
dc.relation.isPartOf | CLINICAL GENITOURINARY CANCER | - |
dc.citation.title | CLINICAL GENITOURINARY CANCER | - |
dc.citation.volume | 18 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 402 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | MOLECULAR URINE ASSAY | - |
dc.subject.keywordPlus | DIGITAL RECTAL EXAMINATION | - |
dc.subject.keywordPlus | HEALTH INDEX | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | CLINICAL UTILITY | - |
dc.subject.keywordPlus | REPEAT BIOPSY | - |
dc.subject.keywordPlus | TUMOR VOLUME | - |
dc.subject.keywordPlus | JAPANESE MEN | - |
dc.subject.keywordPlus | PCA3 SCORE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Diagnosis | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Prostate cancer antigen 3 | - |
dc.subject.keywordAuthor | Prostatic neoplasms | - |
dc.subject.keywordAuthor | Prostate-specific antigen | - |
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