Multi-Class ASD Classification Based on Functional Connectivity and Functional Correlation Tensor via Multi-Source Domain Adaptation and Multi-View Sparse Representation

Abstract

The resting-state functional magnetic resonance imaging (rs-fMRI) reflects functional activity of brain regions by blood-oxygen-level dependent (BOLD) signals. Up to now, many computer-aided diagnosis methods based on rs-fMRI have been developed for Autism Spectrum Disorder (ASD). These methods are mostly the binary classification approaches to determine whether a subject is an ASD patient or not. However, the disease often consists of several sub-categories, which are complex and thus still confusing to many automatic classification methods. Besides, existing methods usually focus on the functional connectivity (FC) features in grey matter regions, which only account for a small portion of the rs-fMRI data. Recently, the possibility to reveal the connectivity information in the white matter regions of rs-fMRI has drawn high attention. To this end, we propose to use the patch-based functional correlation tensor (PBFCT) features extracted from rs-fMRI in white matter, in addition to the traditional FC features from gray matter, to develop a novel multi-class ASD diagnosis method in this work. Our method has two stages. Specifically, in the first stage of multi-source domain adaptation (MSDA), the source subjects belonging to multiple clinical centers (thus called as source domains) are all transformed into the same target feature space. Thus each subject in the target domain can be linearly reconstructed by the transformed subjects. In the second stage of multi-view sparse representation (MVSR), a multi-view classifier for multi-class ASD diagnosis is developed by jointly using both views of the FC and PBFCT features. The experimental results using the ABIDE dataset verify the effectiveness of our method, which is capable of accurately classifying each subject into a respective ASD sub-category.