Association between the IL10 rs1800896 Polymorphism and Tardive Dyskinesia in Schizophrenia
DC Field | Value | Language |
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dc.contributor.author | Choi, Kwang-Yeon | - |
dc.contributor.author | Choo, Jeong Min | - |
dc.contributor.author | Lee, Youn-Jung | - |
dc.contributor.author | Lee, Yujin | - |
dc.contributor.author | Cho, Chul-Hyun | - |
dc.contributor.author | Kim, Seung-Hyun | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.date.accessioned | 2021-08-30T12:57:30Z | - |
dc.date.available | 2021-08-30T12:57:30Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/52621 | - |
dc.description.abstract | Objective Interieuldn-10 (IL-10) is a major immunoregutatorycytokine and its gene plays a fundamental role in anti inflammatory and immunosuppressive activity. This study aimed to examine the association between the IL10 gene promoter -1082G/A polymorphism (rs1800896) and tardive dyskinesia (TD) in schizophrenia. Methods Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). TD was diagnosed using the Research Diagnostic Criteria kw TD and Abnormal Involuntary Movement Scale (AIMS). Genotyping was per-limited by RT-PCR and high-resolution melting curve analysis. Results The distributions of genotypic frequencies did not differ between patients with and without TD (chi(2) =4.33, p=0.115). However, allelic frequencies of the two groups were different (chi(2) =4.45, p=0.035); the A allele frequency was higher in TD. The total AIMS scores of the three genotypes were not different (F=133, p=0.266). However, the total AIMS scores of the A allele carrier and the A allele non-carrier were significantly different (t=5.79, p<0.001). Logistic regression analaysis showed that IL10 -1082G/A genotype significantly predicts presence of TD (p=0.045) after adjusting for covariates such as age and treatment duration. Conclusion This finding suggests that the A allele of rs1800896 may be associated with TD development following a low IL-10 function. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROPSYCHIATRIC ASSOC | - |
dc.subject | NO EVIDENCE | - |
dc.subject | GENE | - |
dc.subject | INTERLEUKIN-10 | - |
dc.title | Association between the IL10 rs1800896 Polymorphism and Tardive Dyskinesia in Schizophrenia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Heon-Jeong | - |
dc.identifier.doi | 10.30773/pi.2020.0191 | - |
dc.identifier.scopusid | 2-s2.0-85093838231 | - |
dc.identifier.wosid | 000579885300008 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, v.17, no.10, pp.1031 - 1036 | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.citation.title | PSYCHIATRY INVESTIGATION | - |
dc.citation.volume | 17 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1031 | - |
dc.citation.endPage | 1036 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002638408 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | NO EVIDENCE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | INTERLEUKIN-10 | - |
dc.subject.keywordAuthor | Tardive dyskinesia | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Interleukin-10 | - |
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