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Cited 2 time in webofscience Cited 2 time in scopus
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Icariin-Functionalized Nanodiamonds to Enhance Osteogenic Capacity In Vitro

Authors
Choi, SomangNoh, Sung HyunLim, Chae OukKim, Hak-JunJo, Han-SaemMin, Ji SeonPark, KyeongsoonKim, Sung Eun
Issue Date
10월-2020
Publisher
MDPI
Keywords
icariin; nanodiamonds; osteogenesis promotion
Citation
NANOMATERIALS, v.10, no.10
Indexed
SCIE
SCOPUS
Journal Title
NANOMATERIALS
Volume
10
Number
10
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/52668
DOI
10.3390/nano10102071
ISSN
2079-4991
Abstract
Nanodiamonds (NDs) have been used as drug delivery vehicles due to their low toxicity and biocompatibility. Recently, it has been reported that NDs have also osteogenic differentiation capacity. However, their capacity using NDs alone is not enough. To significantly improve their osteogenic activity, we developed icariin (ICA)-functionalized NDs (ICA-NDs) and evaluated whether ICA-NDs enhance their in vitro osteogenic capacity. Unmodified NDs and ICA-NDs showed nanosized particles that were spherical in shape. The ICA-NDs achieved a prolonged ICA release for up to 4 weeks. The osteogenic capacities of NDs, ICA (10 mu g)-NDs, and ICA (50 mu g)-NDs were demonstrated by alkaline phosphatase (ALP) activity; calcium content; and mRNA gene levels of osteogenic-related markers, including ALP, runt-related transcript factor 2 (RUNX2), collagen type I alpha 1 (COL1A1), and osteopontin (OPN). In vitro cell studies revealed that ICA (50 mu g)-ND-treated MC3T3-E1 cells greatly increased osteogenic markers, including ALP, calcium content, and mRNA gene levels of osteogenic-related markers, including ALP, RUNX2, COL1A1, and OPN compared to ICA (10 mu g)-NDs or ND-treated cells. These our data suggest that ICA-NDs can promote osteogenic capacity.
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