Gamma-glutamyl transferase variability and risk of dementia: A nationwide study
- Authors
- Lee, You-Bin; Han, Kyungdo; Park, Sanghyun; Kim, Seon Mee; Kim, Nan Hee; Choi, Kyung Mook; Baik, Sei Hyun; Park, Yong Gyu; Yoo, Hye Jin
- Issue Date
- 10월-2020
- Publisher
- WILEY
- Keywords
- Alzheimer' s disease; dementia; gamma-glutamyl transferase; variability; vascular dementia
- Citation
- INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v.35, no.10, pp.1105 - 1114
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- Volume
- 35
- Number
- 10
- Start Page
- 1105
- End Page
- 1114
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/52705
- DOI
- 10.1002/gps.5332
- ISSN
- 0885-6230
- Abstract
- Objectives Variability in various biomarkers has emerged as a new clinical indicator for diseases including neurodegenerative disorders. Gamma-glutamyl transferase (GGT) has a potential to be involved in the pathogenesis of dementia due to its function as a marker of oxidative stress and atherosclerosis. We investigated the association between baseline GGT, GGT variability, and dementia risk for the first time in a large population. Methods The Korean National Health Insurance Service datasets of claims and preventive health check-ups from 2004 to 2016 were used for this retrospective longitudinal study. The risk of incident dementia (all-cause dementia, Alzheimer's disease, and vascular dementia) was analyzed according to sex-specific quartiles of baseline GGT and GGT variability, and groups categorized by baseline GGT and GGT variability in >= 40-year-old individuals without baseline dementia (N = 6 046 442; mean follow-up 6.32 years). Results During follow-up, 166 851 cases of new dementia developed. The fully adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident dementia increased in the higher quartiles of baseline GGT and GGT variability (HR [95% CI]: Q2, 1.034 [1.019-1.049]; Q3, 1.090 [1.075-1.105]; Q4, 1.212 [1.196-1.229]). The association between GGT variability quartiles and dementia risk remained significant even after adjusting for log-transformed baseline GGT level. The fully adjusted HRs for dementia was highest in the group with high baseline GGT concentration and the highest GGT variability quartile [HR (95% CI): 1.273 (1.250-1.296)]. Conclusions Not only baseline GGT level, but also GGT variability may be an independent predictor of dementia, and might be used for risk stratification for future dementia.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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