Atrial Substrate Underlies the Recurrence after Catheter Ablation in Patients with Atrial Fibrillation
DC Field | Value | Language |
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dc.contributor.author | Baek, Yong-Soo | - |
dc.contributor.author | Choi, Jong-Il | - |
dc.contributor.author | Kim, Yun Gi | - |
dc.contributor.author | Lee, Kwang-No | - |
dc.contributor.author | Roh, Seung-Young | - |
dc.contributor.author | Ahn, Jinhee | - |
dc.contributor.author | Kim, Dong-Hyeok | - |
dc.contributor.author | Lee, Dae In | - |
dc.contributor.author | Hwang, Sung Ho | - |
dc.contributor.author | Shim, Jaemin | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Kim, Dae-Hyeok | - |
dc.contributor.author | Park, Sang-Weon | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.date.accessioned | 2021-08-30T13:52:31Z | - |
dc.date.available | 2021-08-30T13:52:31Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53055 | - |
dc.description.abstract | Prediction of recurrences after catheter ablation of atrial fibrillation (AF) remains challenging. We sought to investigate the long-term outcomes after AF catheter ablation. A total of 2221 consecutive patients who underwent catheter ablation for symptomatic AF were included in this study (mean age 55 +/- 11 years, 20.3% women, and 59.0% paroxysmal AF). Extensive ablation, in addition to circumferential pulmonary vein isolation, was more often accomplished in patients with non-paroxysmal AF than in those with paroxysmal AF (87.4% vs. 25.3%, p < 0.001). During a median follow-up of 54 months, sinus rhythm (SR) was maintained in 67.1% after index procedure. After redo procedures in 418 patients, 83.3% exhibited SR maintenance. Recurrence rates were similar for single and multiple procedures (17.4% vs. 16.7%, p = 0.765). Subanalysis showed that the extent of late gadolinium enhancement (LGE), as assessed by cardiac magnetic resonance, is greater in patients with recurrence than in those without recurrence (36.2 +/- 23.9% vs. 21.8 +/- 13.7%, p < 0.001). Cox-regression analysis revealed that non-paroxysmal AF (hazard ratio (HR) 2.238, 95% confidence interval (CI) 1.905-2.629, p < 0.001), overweight (HR 1.314, 95% CI 1.107-1.559, p = 0.020), left atrium dimension >= 45 mm (HR 1.284, 95% CI 1.085-1.518, p = 0.004), AF duration (HR 1.020 per year, 95% CI 1.006-1.034, p = 0.004), and LGE >= 25% (HR 1.726, 95% CI 1.330-2.239, p < 0.001) are significantly associated with AF recurrence after catheter ablation. This study showed that repeated catheter ablation improves the clinical outcomes of patients with non-paroxysmal AF, suggesting that AF substrate based on LGE may underpin the mechanism of recurrence after catheter ablation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | MRI | - |
dc.subject | ENHANCEMENT | - |
dc.subject | RISK | - |
dc.title | Atrial Substrate Underlies the Recurrence after Catheter Ablation in Patients with Atrial Fibrillation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jong-Il | - |
dc.contributor.affiliatedAuthor | Kim, Yun Gi | - |
dc.contributor.affiliatedAuthor | Hwang, Sung Ho | - |
dc.contributor.affiliatedAuthor | Shim, Jaemin | - |
dc.identifier.doi | 10.3390/jcm9103164 | - |
dc.identifier.wosid | 000586949900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.9, no.10 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | atrial fibrillation | - |
dc.subject.keywordAuthor | catheter ablation | - |
dc.subject.keywordAuthor | substrate | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
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